Single gene change increases mouse lifespan by 20 percent

NIH intramural study also shows that individual organs are affected differently

By lowering the expression of a single gene, researchers at the National Institutes of Health have extended the average lifespan of a group of mice by about 20 percent — the equivalent of raising the average human lifespan by 16 years, from 79 to 95. The research team targeted a gene called mTOR, which is involved in metabolism and energy balance, and may be connected with the increased lifespan associated with caloric restriction.

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This page was last updated on Friday, January 21, 2022