Sex hormone-sensitive gene complex linked to premenstrual mood disorder

Tuesday, January 3, 2017

Dysregulated cellular response to estrogen and progesterone suspected.

National Institutes of Health (NIH) researchers have discovered molecular mechanisms that may underlie a woman’s susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period. Such premenstrual dysphoric disorder (PMDD) affects 2 to 5 percent of women of reproductive age, whereas less severe premenstrual syndrome (PMS) is much more common.

A straight marked scatter plot chart. Expression of this ESC/E(Z) gene network was found to be systematically disturbed in PMDD.