Sex hormone-sensitive gene complex linked to premenstrual mood disorder

Dysregulated cellular response to estrogen and progesterone suspected.

National Institutes of Health (NIH) researchers have discovered molecular mechanisms that may underlie a woman’s susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period. Such premenstrual dysphoric disorder (PMDD) affects 2 to 5 percent of women of reproductive age, whereas less severe premenstrual syndrome (PMS) is much more common.

A straight marked scatter plot chart. Expression of this ESC/E(Z) gene network was found to be systematically disturbed in PMDD.

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This page was last updated on Friday, January 21, 2022