Oxygen can impair cancer immunotherapy in mice
Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer activity of T cells. Inhibiting the oxygen-sensing capability of immune cells, either genetically or pharmacologically, prevented lung metastasis. This research was conducted by Nicholas Restifo, M.D., Center for Cancer Research, National Cancer Institute (NCI) and others at NCI as well as colleagues at the National Institute of Allergy and Infectious Diseases (NIAID), both parts of the National Institutes of Health. The findings appeared Aug. 25, 2016, in the journal Cell.
This page was last updated on Friday, January 21, 2022