NIH study sheds light on immune responses driving obesity-induced liver disease

Findings in mouse models reveal inflammatory factors that promote liver scarring

New findings from mouse models reveal that the type of immune response that helps maintain healthy metabolism in fatty tissues, called type 2 immunity, also drives obesity-induced nonalcoholic fatty liver disease (NAFLD). The work, led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, shows that the inflammatory environment in the fatty liver is more complex than previously thought. These insights may inform the development of new NAFLD treatments as well as immune-altering therapies for obesity and related health issues in people with NAFLD.

Image of normal mouse liver with steatosis (left) and liver of a mouse lacking IFN-gamma showing markedly higher steatosis

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This page was last updated on Friday, January 21, 2022