NIH Director's Seminar: Deciphering principles of cell-fate decisions through human disease mutations
to
Wilson Hall, NIH Building 1; and NIH videocast
The second lecture lecture in the 2024-2025 NIH Director's Seminar Series will be presented by IRP senior investigator Achim Werner, Ph.D.
Dr. Werner's lab studies the molecular principles of how cell-fate decisions are determined during development. Its studies focus on ubiquitylation, an essential posttranslational modification that is required for cell division, differentiation, and migration in all metazoans. His group leverages the unique environment of the NIH intramural program and combines human pluripotent stem cell culture, proteomics, and ubiquitin biochemistry with animal models, clinical genetics, and human disease cohorts. In this lecture, Dr. Werner will summarize how this integration of expertise with his local colleagues has allowed his team to uncover mechanisms of how ubiquitylation regulates diverse aspects of neuroectodermal and hematopoietic differentiation and to define previously unrecognized neurodevelopmental, craniofacial, and autoinflammatory diseases.
This page was last updated on Tuesday, October 1, 2024