genetics

Next Big Thing in Genome Modification: the CRISPR/Cas9 System

Ever since the discovery of the double-helix structure of DNA, scientists have sought ways to edit the genome. Altering gene expression partially and transiently via small interfering RNA has come a long way, and the progress has been spectacular. However, achieving complete and sustained modification of gene expression in a cell remains a tedious procedure that is often costly and time-consuming. For molecular biologists working with cell lines, quick and efficient knock out of one or more genes would provide a powerful tool for their studies. The CRISPR technology arrived two years ago to potentially fulfill that need.

CRISPR genome editing

Non-Coding RNAs Are Rising Stars in Gene Expression Regulation

During my Ph.D., I decided to pursue my thesis project in a lab working in the RNA field and, more specifically, on the mechanisms of alternative splicing regulation. Moving onto my post-doctoral training, I decided to stay in this field mainly because I found it fascinating to work with RNA. It is such a flexible and diverse molecule, but also largely unexplored. I believed that this relatively new area of research would attract more interest among scientists, and the last few years show that I was thinking in the right direction.

RNA Rising Stars