Jeffery K. Taubenberger, M.D., Ph.D.

Senior Investigator

Viral Pathogenesis & Evolution Section

NIAID/DIR

Building 33, Room 3E19A.3
33 North Drive
Bethesda, MD 20892

301-443-5960

taubenbergerj@niaid.nih.gov

Research Topics

The Viral Pathogenesis and Evolution Section seeks to address fundamental questions of influenza virus pathogenesis in different animal hosts, including the mapping of viral virulence factors and mutations associated with host adaptation, as well as characterizing the host response to infection. The role of secondary bacterial infections in influenza infection is being examined. Experiments are also being performed to evaluate novel therapeutics for the treatment of severe influenza and to evaluate the significance of heterosubtypic and heterotypic immunity to influenza viral antigens.

The section studies viral evolution and fitness through the development of improved viral surveillance and genomics. These efforts employ both in vitro assays and experimental animal model systems. These studies seek to understand the dynamics of viral evolution in different hosts, including birds, mammals, and the evolutionary dynamics of human pandemic and seasonal influenza viruses.

Since completing the sequencing of the 1918 pandemic viral genome, the section has maintained an interest in archaevirology and is seeking to characterize pre- and post-1918 influenza virus genomes from archival samples.

The section also performs translational research involving clinical trials addressing pandemic and seasonal influenza viral infections in patients with and without immunocompromise. These investigations include characterization of the development of antiviral resistance mutations, intra-host viral evolution, and characterization of the host immune response. Postmortem examinations of lung tissue from fatal cases of pandemic and seasonal influenza are employed to understand the development of severe influenza viral disease in humans. The section has recently begun a human volunteer influenza virus challenge study. Finally, the section continues to develop novel molecular genetic assays for influenza viruses for diagnosis, surveillance, and mutation screening.

Together, such investigations will help shed light on the emergence, evolution, and severity of influenza pandemics as well as seasonal influenza.

Biography

Dr. Taubenberger received a B.S. in biology from George Mason University in 1982. He earned his medical degree in 1986 and his Ph.D. in 1987, both from the Medical College of Virginia. He completed a residency in pathology at the National Cancer Institute and holds dual board certifications in anatomic pathology and in molecular genetic pathology from the American Board of Pathology and the American Board of Medical Genetics. Prior to coming to NIAID in 2006, he served as chair of the Department of Molecular Pathology at the Armed Forces Institute of Pathology in Washington, DC, a position he held since 1994. Dr. Taubenberger’s research interests include influenza virus biology, evolution, pathophysiology, and surveillance. He also has clinical interests in the development and implementation of molecular diagnostic assays for neoplasia and infectious diseases.

Memberships

  • American Society for Microbiology
  • American Academy of Microbiology
  • Association of American Physicians

Editorial Boards

  • Virology

Selected Publications

  1. Walters KA, D'Agnillo F, Sheng ZM, Kindrachuk J, Schwartzman LM, Kuestner RE, Chertow DS, Golding BT, Taubenberger JK, Kash JC. 1918 pandemic influenza virus and Streptococcus pneumoniae co-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans. J Pathol. 2016;238(1):85-97.

  2. Schwartzman LM, Cathcart AL, Pujanauski LM, Qi L, Kash JC, Taubenberger JK. An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus. MBio. 2015;6(4):e01044.

  3. Kash JC, Walters KA, Kindrachuk J, Baxter D, Scherler K, Janosko KB, Adams RD, Herbert AS, James RM, Stonier SW, Memoli MJ, Dye JM, Davey RT Jr, Chertow DS, Taubenberger JK. Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease. Sci Transl Med. 2017;9(385).

  4. Xiao YL, Kash JC, Beres SB, Sheng ZM, Musser JM, Taubenberger JK. High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic. J Pathol. 2013;229(4):535-45.

  5. Memoli MJ, Shaw PA, Han A, Czajkowski L, Reed S, Athota R, Bristol T, Fargis S, Risos K, Powers JH, Davey RT Jr, Taubenberger JK. Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model. MBio. 2016;7(2):e00417-16.


This page was last updated on March 15th, 2017