NIH researchers find potential genetic cause of Cushing syndrome

Finding may lead to therapies that prevent pituitary tumor recurrence.

A small study by researchers at the National Institutes of Health suggests that mutations in the gene CABLES1 may lead to Cushing syndrome, a rare disorder in which the body overproduces the stress hormone cortisol. The study appears online in Endocrine-Related Cancer.

The excess cortisol found in Cushing syndrome can result from certain steroid medications or from tumors of the pituitary or adrenal glands. Symptoms of the disease include obesity, muscle weakness, fatigue, high blood pressure, high blood sugar, depression and anxiety.

NIH researchers find potential genetic cause of Cushing syndrome

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This page was last updated on Friday, January 21, 2022