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I am Intramural Blog

opioid use disorder

Suppressing Neurons Curbs Withdrawal-Induced Pain Hypersensitivity

Insights From Mouse Study Could Aid Treatment for Opioid Use Disorder

Tuesday, October 24, 2023

man with neck pain

A headache or stubbed toe is annoying enough as it is, but for people in recovery from opioid use disorder, everyday aches and pains — and even sensations that would ordinarily not be painful at all — can be amped up to the point that they become quite distressing. A new IRP mouse study has helped scientists home in on the specific brain cells that might cause this phenomenon, providing a first step towards an intervention that could make it easier for people to stop using addictive opioid medications or illegal drugs like heroin.

Examining the Roots of Opioid Use Disorder

IRP Researchers Are Peering Into the Brain to Learn Why Opioid Drugs Are So Hard to Quit

Monday, March 13, 2023

oxycodone pills and pill bottle

The ancient Egyptians, despite their significant anatomical knowledge, thought the heart was the seat of intelligence. Over the millennia, that view changed as philosophers and scientists alike came to appreciate the extraordinary role of the brain. It is partly thanks to them that we celebrate Brain Awareness Week every March. In honor of this observance, we took the opportunity to talk with IRP senior investigator Yihong Yang, Ph.D., and postdoctoral fellow Ida Fredriksson, Ph.D., Pharm.D., about their investigation into how cravings for opioids build during a period of prolonged abstinence, often leading to relapse.

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