Breaking down complex autoinflammatory diseases, and building up new hope
In some individuals, the immune system attacks the body’s own tissues, causing inflammation. The recent discovery that a subset of autoinflammatory diseases has genetic components complicates diagnosis, making development of therapeutics a challenge.
IRP researcher Daniel L. Kastner, M.D., Ph.D., and colleagues identified, classified, and characterized more than 10 new hereditary autoinflammatory disease pathways, including FMF, TRAPS, NOMID, and DIRA. IRP scientists develop and test new therapies aimed at reducing inflammation in these diseases, in some cases completely reversing them.
Patients with complex genetic autoinflammatory disorders may soon no longer need to experience trial and error prescribing in an effort to control their debilitating symptoms. For some diseases, genetic analyses combined with molecular studies of the affected pathways can inform the selection of targeted therapeutics and provide immediate and sustained relief.
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