
Christa S. Zerbe, M.D., M.S.
Senior Clinician
Laboratory of Clinical Immunology & Microbiology
NIAID/DIR
Research Topics
As a Senior Clinician, Dr. Zerbe focuses on the clinical care of patients with CGD and acquired anti-cytokine antibody syndromes. Her research includes studies in patients with anti-cytokine antibodies both nationally and internationally in Thailand continuing the research and treatment of patients who suffer from these syndromes in order to further our understanding of non-HIV acquired immunodeficiency. Additionally, Dr. Zerbe oversees the care and research regarding patients with and affected carriers of the gene resulting in Chronic Granulomatous Disease. Her collaboration with the NIDDK and with outside collaborators resulted in a UO1 grant as well as several protocols looking at therapies aimed at the inflammatory complications in this disease.
Biography
An alumnus of The University of Pittsburgh School of Medicine, Dr. Zerbe completed her Internal Medicine residency at the University of Maryland Hospital before transitioning into the ABIM Research Pathway for Infectious Disease Fellowship at the NIH. Dr. Zerbe serves as Principal Investigator on numerous protocols within NIAID. She is the director of the Infectious Disease training program at the NIH and recently began overseeing the joint NIH-Johns Hopkins Hospital Transplant Oncology ID training program.
Selected Publications
- Sparks R, Rachmaninoff N, Lau WW, Hirsch DC, Bansal N, Martins AJ, Chen J, Liu CC, Cheung F, Failla LE, Biancotto A, Fantoni G, Sellers BA, Chawla DG, Howe KN, Mostaghimi D, Farmer R, Kotliarov Y, Calvo KR, Palmer C, Daub J, Foruraghi L, Kreuzburg S, Treat JD, Urban AK, Jones A, Romeo T, Deuitch NT, Moura NS, Weinstein B, Moir S, Ferrucci L, Barron KS, Aksentijevich I, Kleinstein SH, Townsley DM, Young NS, Frischmeyer-Guerrerio PA, Uzel G, Pinto-Patarroyo GP, Cudrici CD, Hoffmann P, Stone DL, Ombrello AK, Freeman AF, Zerbe CS, Kastner DL, Holland SM, Tsang JS. A unified metric of human immune health. Nat Med. 2024;30(9):2461-2472.
- Blackburn BG, Leuck AM, Phadke VK, Van Schooneveld T, Sanasi-Bhola K, Simms AT, Angarone M, Balba G, Wooten D, Babik JM, Bartash R, Bhowmick T, Osorio G, Katzman JH, Solomon DA, Bhanot N, Tischendorf JS, Blyth DM, Acharya KB, Weber DM, Burke V, Cunha CB, Carey A, Wood E, Zerbe CS. Infectious Diseases Fellowship Curriculum: IDSA Training Program Directors Community of Practice (TPDCOP), Curricular and Educational REsources Workgroup (CREW). Clin Infect Dis. 2026.
- Cheng A, Kashyap A, Salvator H, Rosen LB, Colby D, Ardeshir-Larijani F, Loehrer PJ, Ding L, Lugo Reyes SO, Riminton S, Ballman M, Rocco JM, Marciano BE, Freeman AF, Browne SK, Hsu AP, Zelazny A, Rajan A, Sereti I, Zerbe CS, Lionakis MS, Holland SM. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. N Engl J Med. 2024;390(12):1105-1117.
- Sakai S, Namasivayam S, Kauffman KD, Fukutani E, Queiroz ATL, Nelson CE, McCaffrey EF, Chetchotisakd P, Buchanan J, Sher A, Feng CG, Ernst JD, Holland SM, Mayer-Barber KD, Andrade BB, Zerbe CS, Via LE, Barber DL. IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control. Nat Commun. 2026;17(1).
Related Scientific Focus Areas

Microbiology and Infectious Diseases
View additional Principal Investigators in Microbiology and Infectious Diseases

This page was last updated on Saturday, August 29, 2026