Christa S. Zerbe, M.D., M.S.

Senior Clinician

Laboratory of Clinical Immunology & Microbiology

NIAID/DIR

Building 10, Room 12C110
10 Center Drive
Bethesda, MD 20892

301-594-5932

zerbech@niaid.nih.gov

Research Topics

As a Senior Clinician, Dr. Zerbe focuses on the clinical care of patients with CGD and acquired anti-cytokine antibody syndromes. Her research includes studies in patients with anti-cytokine antibodies both nationally and internationally in Thailand continuing the research and treatment of patients who suffer from these syndromes in order to further our understanding of non-HIV acquired immunodeficiency. Additionally, Dr. Zerbe oversees the care and research regarding patients with and affected carriers of the gene resulting in Chronic Granulomatous Disease. Her collaboration with the NIDDK and with outside collaborators resulted in a UO1 grant as well as several protocols looking at therapies aimed at the inflammatory complications in this disease.

Biography

An alumnus of The University of Pittsburgh School of Medicine, Dr. Zerbe completed her Internal Medicine residency at the University of Maryland Hospital before transitioning into the ABIM Research Pathway for Infectious Disease Fellowship at the NIH. Dr. Zerbe serves as Principal Investigator on numerous protocols within NIAID. She is the director of the Infectious Disease training program at the NIH and recently began overseeing the joint NIH-Johns Hopkins Hospital Transplant Oncology ID training program.

Selected Publications

  1. Sparks R, Rachmaninoff N, Lau WW, Hirsch DC, Bansal N, Martins AJ, Chen J, Liu CC, Cheung F, Failla LE, Biancotto A, Fantoni G, Sellers BA, Chawla DG, Howe KN, Mostaghimi D, Farmer R, Kotliarov Y, Calvo KR, Palmer C, Daub J, Foruraghi L, Kreuzburg S, Treat JD, Urban AK, Jones A, Romeo T, Deuitch NT, Moura NS, Weinstein B, Moir S, Ferrucci L, Barron KS, Aksentijevich I, Kleinstein SH, Townsley DM, Young NS, Frischmeyer-Guerrerio PA, Uzel G, Pinto-Patarroyo GP, Cudrici CD, Hoffmann P, Stone DL, Ombrello AK, Freeman AF, Zerbe CS, Kastner DL, Holland SM, Tsang JS. A unified metric of human immune health. Nat Med. 2024.
  2. Luther VP, Paras ML, Schultz S, Aziz M, Balba G, McCarty TP, Razonable RR, Reece R, Shnekendorf R, Sundareshan V, Chirch LM, Infectious Diseases Society of America Infectious Diseases Training Program Directors Committee and Working Group. High-Volume, High-Acuity, and High-Impact Learning: Tips and Tricks for Infectious Diseases Training Programs. Open Forum Infect Dis. 2024;11(3):ofae016.
  3. Zendt M, Bustos Carrillo FA, Kelly S, Saturday T, DeGrange M, Ginigeme A, Wu L, Callier V, Ortega-Villa A, Faust M, Chang-Rabley E, Bugal K, Kenney H, Khil P, Youn JH, Osei G, Regmi P, Anderson V, Bosticardo M, Daub J, DiMaggio T, Kreuzburg S, Pala F, Pfister J, Treat J, Ulrick J, Karkanitsa M, Kalish H, Kuhns DB, Priel DL, Fink DL, Tsang JS, Sparks R, Uzel G, Waldman MA, Zerbe CS, Delmonte OM, Bergerson JRE, Das S, Freeman AF, Lionakis MS, Sadtler K, van Doremalen N, Munster V, Notarangelo LD, Holland SM, Ricotta EE. Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies. Sci Adv. 2023;9(41):eadh3150.
  4. Cheng A, Kashyap A, Salvator H, Rosen LB, Colby D, Ardeshir-Larijani F, Loehrer PJ, Ding L, Lugo Reyes SO, Riminton S, Ballman M, Rocco JM, Marciano BE, Freeman AF, Browne SK, Hsu AP, Zelazny A, Rajan A, Sereti I, Zerbe CS, Lionakis MS, Holland SM. Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. N Engl J Med. 2024;390(12):1105-1117.
  5. Chandrasekaran P, Han Y, Zerbe CS, Heller T, DeRavin SS, Kreuzberg SA, Marciano BE, Siu Y, Jones DR, Abraham RS, Stephens MC, Tsou AM, Snapper S, Conlan S, Subramanian P, Quinones M, Grou C, Calderon V, Deming C, Leiding JW, Arnold DE, Logan BR, Griffith LM, Petrovic A, Mousallem TI, Kapoor N, Heimall JR, Barnum JL, Kapadia M, Wright N, Rayes A, Chandra S, Broglie LA, Chellapandian D, Deal CL, Grunebaum E, Lim SS, Mallhi K, Marsh RA, Murguia-Favela L, Parikh S, Touzot F, Cowan MJ, Dvorak CC, Haddad E, Kohn DB, Notarangelo LD, Pai SY, Puck JM, Pulsipher MA, Torgerson TR, Kang EM, Malech HL, Segre JA, Bryant CE, Holland SM, Falcone EL. Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease. J Allergy Clin Immunol. 2023;152(6):1619-1633.e11.

Related Scientific Focus Areas

This page was last updated on Monday, September 9, 2024