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Paul E. Love, M.D., Ph.D.

Senior Investigator
NICHD
Section on Cellular and Developmental Biology
Building 6B, Room 2B210
6 Center Drive
Bethesda, MD 20892
301-402-4946

Research Topics

Genes and Signals Regulating Mammalian Hematopoiesis

Our research focuses on the development of the mammalian hematopoietic system. Of particular interest is the characterization of signal transduction molecules and pathways that regulate T cell maturation in the thymus. Current projects include the generation of transgenic and conditional deletion mutants to evaluate the importance of T cell antigen receptor signaling at specific stages of T cell development. We are also using microarray gene profiling to identify molecules that are important for thymocyte selection, a process that promotes the survival and development of functional T cells and the death of auto-reactive T cells. Further, we are analyzing the function of Themis, a T cell–specific signaling protein newly identified by our laboratory.  A recently initiated area of investigation focuses on hematopoietic stem cells (HSCs). We have begun to characterize the genes that are important for the generation and maintenance of HSCs and for their differentiation into specific hematopoietic lineages. These studies have revealed a critical function for one protein (Ldb1) in controlling the self-renewal/differentiation cell-fate decision in hematopoietic stem cells.

Biography

Dr. Paul Love earned a B.S. degree in Biochemistry from Syracuse University in 1979 and received an M.D. and Ph.D. from the University of Rochester in 1987. He completed a residency program in Laboratory Medicine at Washington University, St. Louis and a fellowship in Human Genetics in NICHD, before joining the laboratory of Dr. Heiner Westphal (NICHD) as a postdoctoral research fellow. He became an intramural Principal Investigator in 1993 and is now a tenured Senior Investigator and head of the Section on Cellular & Developmental Biology in NICHD. The research focus of Dr. Love’s lab is in the area of mammalian hematopoiesis. The lab has a long history of studying the process of T cell development, which begins with migration of multipotent progenitor cells, derived from hematopoietic stem cells in the bone marrow, to the thymus. Immature T cells then undergo a series of developmental steps in the thymus, including a process of selection that promotes the development of functional cells and the deletion of overtly self-reactive cells, ultimately leading to the generation of mature “self-tolerant” T lymphocytes that exit the thymus and populate the peripheral lymphoid organs. Dr. Love’s group has investigated questions relating to each of these steps in the T cell developmental pathway over the years; however, the main focus of his lab is the role and importance of signals transduced by the T cell antigen receptor (TCR) for T cell maturation. Current work includes studies aimed at understanding how TCR signaling influences susceptibility to autoimmune disease and investigating potential therapeutic interventions for the treatment of human hematopoietic stem cell malignancies.

Selected Publications

  1. Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE. Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009;10(8):840-7.
  2. Li L, Lee JY, Gross J, Song SH, Dean A, Love PE. A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med. 2010;207(12):2543-50.
  3. Li L, Jothi R, Cui K, Lee JY, Cohen T, Gorivodsky M, Tzchori I, Zhao Y, Hayes SM, Bresnick EH, Zhao K, Westphal H, Love PE. Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol. 2011;12(2):129-36.
  4. Love PE, Bhandoola A. Signal integration and crosstalk during thymocyte migration and emigration. Nat Rev Immunol. 2011;11(7):469-77.
This page was last updated on January 5th, 2012