Masur Auditorium, NIH Clinical Center (Bldg 10)
Join us for the Annual DeWitt Stetten, Jr., Lecture with Ron Vale, Ph.D., of UCSF, titled “The mechanisms of cytoskeletal motor proteins." The lecture is part of the Wednesday Afternoon Lecture Series (WALS). Vale is an HHMI investigator and Professor and Vice-Chair, Department of Cellular and Molecular Pharmacology, at UCSF.
about the speaker: The Vale Lab combines cell biological and biophysical approaches to understand spatial organization, movement, and signaling within cells. The lab integrates biochemical, structural, and microscopy-based approaches to study these questions at scales that span from atomic information of proteins to the behavior of cells in living organisms. At the smallest scale, we wish to understand the detailed workings of protein machines. A particular focus of our lab is on microtubule-based "motor proteins" that convert energy from ATP hydrolysis into unidirectional motion and force. We have concentrated for many years on the kinesin motor protein although more of our current emphasis has shifted to dynein. The lab also is interested in understanding the mechanisms of various other proteins, including microtubule nucleating factors (augmin), microtubule regulatory proteins (severing proteins, end binding proteins), and the T cell receptor. The lab also wishes to understand how collections of protein machines function together to generate complex behavior in living cells. As examples, they are currently interested in how numerous proteins function in building the mitotic spindle, generate specific cell shapes, transport mRNAs, and produce signaling responses in T cells. In these efforts, they use various types of microscopy to analyze cell behavior in culture or in living animals, examine consequences of gene knockdown (RNAi), and also engineer cells that exhibit new properties by introducing specific genes.