Patricia Jensen, Ph.D.
Neurobiology Laboratory / Developmental Neurobiology Group
Building 101, Room F118
111 T.W. Alexander Drive
Research Triangle Park, NC 27709
Central norepinephrine (NE)-producing neurons comprise a diverse population of cells differing in their anatomical location, connectivity, function and response to disease and environmental insult. The goal of my lab is to understand how diversity arises among functionally distinct subtypes of NE neurons, and how the fates and functions of these different subtypes are altered following genetic and environmental perturbations during development. Towards addressing these goals, we have developed a novel set of genetic mouse models to visualize and manipulate select subtypes of NE neurons in vivo. These tools provide, for the first time, a means to determine the effect of altered NE signaling during development on circuits underlying behaviors such as attention and learning & memory.
Dr. Patricia Jensen received her Ph.D. in Anatomy and Neurobiology at The University of Tennessee Health Science Center in 2002 under Dr. Dan Goldowitz. She trained with Dr. Tom Curran in Developmental Neurobiology at St. Jude Children's Research Hospital, and Dr. Susan Dymecki in Genetics at Harvard Medical School before joining NIEHS at a Tenure-Track Investigator in 2009.
Bang SJ, Jensen P, Dymecki SM, Commons KG. Projections and interconnections of genetically defined serotonin neurons in mice. Eur J Neurosci. 2012;35(1):85-96.
Jensen P, Farago AF, Awatramani RB, Scott MM, Deneris ES, Dymecki SM. Redefining the serotonergic system by genetic lineage. Nat Neurosci. 2008;11(4):417-9.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006;4(4):e86.
Jensen P, Smeyne R, Goldowitz D. Analysis of cerebellar development in math1 null embryos and chimeras. J Neurosci. 2004;24(9):2202-11.
Jensen P, Zoghbi HY, Goldowitz D. Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J Neurosci. 2002;22(18):8110-6.