Maria L. Dufau, M.D., Ph.D.
Section on Molecular Endocrinology
Building 49, Room 6A36
49 Convent Drive
Bethesda, MD 20892
Molecular basis of the hormonal control of gonadal function with emphasis on the gene structure and regulation of the human luteinizing hormone receptor (repression and de-repression mechanisms, epigenetics, signal transduction); multiple promoter control of human prolactin receptor gene transcription by steroids and growth factors; elucidation of the function of the short forms of the prolactin receptor and their relevance to physiological regulation and breast cancer; the regulatory mechanism involved in the progress of spermatogenesis and Leydig cell function including the identification and functional characterization of a novel regulatory genes (i.e. Gonadotropin Regulated Testicular RNA Helicase- GRTH/DDX25, discovered in this laboratory) that participate in the progression of testicular gametogenesis, Leydig cell function and other endocrine processes.
Dufau ML, Liao M, Zhang Y. Participation of signaling pathways in the derepression of luteinizing hormone receptor transcription. Mol Cell Endocrinol. 2010;314(2):221-7.
Sato H, Tsai-Morris CH, Dufau ML. Relevance of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) in the structural integrity of the chromatoid body during spermatogenesis. Biochim Biophys Acta. 2010;1803(5):534-43.
Liao M, Zhang Y, Kang JH, Dufau ML. Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. J Biol Chem. 2011;286(9):7681-91.
Kang JH, Tsai-Morris CH, Dufau ML. Complex formation and interactions between transcription factors essential for human prolactin receptor gene transcription. Mol Cell Biol. 2011;31(16):3208-22.
Fukushima M, Villar J, Tsai-Morris CH, Dufau ML. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR). J Biol Chem. 2011;286(34):29932-40.