
Molecular basis of the hormonal control of gonadal function with emphasis on the gene structure and regulation of the human luteinizing hormone receptor (repression and de-repression mechanisms, epigenetics, signal transduction); multiple promoter control of human prolactin receptor gene transcription by steroids and growth factors; elucidation of the function of the short forms of the prolactin receptor and their relevance to physiological regulation and breast cancer; the regulatory mechanism involved in the progress of spermatogenesis and Leydig cell function including the identification and functional characterization of a novel regulatory genes (i.e. Gonadotropin Regulated Testicular RNA Helicase- GRTH/DDX25, discovered in this laboratory) that participate in the progression of testicular gametogenesis, Leydig cell function and other endocrine processes.
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