Elaine S. Jaffe, M.D.
Laboratory of Pathology
Building 10, Room 3S235
Bethesda, MD 20892-1500
Lymphoma Disease Discovery and Definition
Disease discovery and disease definition are critical first steps in elucidating pathogenetic mechanisms of cancer. Most insights into the molecular pathogenesis of lymphomas have followed on the heels of a precise elucidation of the disease entity based on clinical, pathological, or immunophenotypic grounds. Our work focuses on the definition of malignant lymphomas as tumors of the immune system, delineation of new disease entities, studies related to the pathophysiology of malignant lymphomas, and clinical correlations including prognosis and response to treatment. These studies in our laboratory and others were instrumental in the development of the WHO Classification of Tumours of the Hematopoietic and Lymphoid Tissues was published by the International Agency for Research on Cancer, published in 2001 and revised in 2008.
Our recent work has involved studies of the biological and pathological heterogeneity of follicular lymphomas, and an investigation of apoptotic pathways in these tumors. We have explored the interrelationship between Hodgkin lymphoma and diffuse large B-cell lymphomas, focusing in particular on grey zone lymphomas that appear to represent the missing link between classical Hodgkin lymphoma and other B-cell malignancies. Ongoing studies are directed at trying to understand the genetic or epigenetic mechanisms that cause a B-cell to become a Hodgkin cell,and understanding the role of the microenvironment in these lymphomas. We also are studying early events in lymphomagenesis and in particular, in follicular lymphomas we are exploring the genetic changes that distinguish follicular lymphoma in situ from follicular lymphoma.
Cong P, Raffeld M, Teruya-Feldstein J, Sorbara L, Pittaluga S, Jaffe ES. In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. Blood. 2002;99(9):3376-82.
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M, Camos M, Warnke R, Jaffe ES. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood. 2008;111(12):5433-9.
Mansoor A, Pittaluga S, Beck PL, Wilson WH, Ferry JA, Jaffe ES. NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series. Blood. 2011;117(5):1447-52.
Traverse-Glehen A, Pittaluga S, Gaulard P, Sorbara L, Alonso MA, Raffeld M, Jaffe ES. Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma. Am J Surg Pathol. 2005;29(11):1411-21.
Jaffe ES, Shevach EM, Frank MM, Berard CW, Green I. Nodular lymphoma--evidence for origin from follicular B lymphocytes. N Engl J Med. 1974;290(15):813-9.