Clifton I. Bogardus, III, M.D.
Senior Investigator
Phoenix Epidemiology & Clinical Research Branch
NIDDK
Research Topics
The goal of our research is to determine the etiology of type 2 diabetes mellitus and obesity and their complications to improve prevention and treatment.
Current Research
Our research goal is to determine the role of genetic and physiologic factors in the etiology of type 2 diabetes mellitus and obesity and their complications. We use genome-wide association studies to identify variants associated with type 2 diabetes, obesity, and pre-diabetic/pre-obesity traits in specific populations. We look at expression data from skeletal muscle and adipose biopsies to identify expression profiles and metabolic traits that may predict disease onset. Identifying, quantifying, and understanding specific genetically determined susceptibility or protective factors could lead to prevention by identifying individuals at risk and to improved treatment.
Applying our Research
Identifying the specific etiologies of type 2 diabetes mellitus and obesity will lead to improved prevention and treatments.
Need for Further Study
The prevalence of obesity and type 2 diabetes mellitus is increasing throughout the developed and developing world and disproportionally affects minority populations. The causes of these conditions are complex and include genetic, environmental, and lifestyle factors that may vary between populations. To improve prevention and treatments, more research is needed to identify the specific factors increasing susceptibility to these conditions in different populations.
Biography
- Chief, Phoenix Epidemiology and Clinical Research Branch, NIDDK, NIH, 2000–present
- Chief, Clinical Diabetes and Nutrition Section, NIDDK, NIH, 1985–2000
- NIH Clinical Research Training Fellowship, University of Vermont, 1979–1982
- Internal Medicine Residency, Dartmouth - Hitchcock Medical Center, 1977–1979
- Commander, U.S. Army Health Clinic, 1975–1977
- Internal Medicine Internship, Dartmouth - Hitchcock Medical Center, 1974–1975
- M.D., University of Rochester School of Medicine, 1974
- B.S., Lafayette College, 1970
Selected Publications
- Nair AK, Traurig M, Sutherland JR, Muller YL, Grellinger ED, Saporito L, Nelson RG, Bogardus C, Baier LJ. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. Cells. 2022;11(9).
- Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. Diabetes. 2016;65(2):510-9.
- Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr. 2011;94(1):58-65.
- Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C. ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes. Diabetes. 2015;64(12):4322-32.
- Hanson RL, Guo T, Muller YL, Fleming J, Knowler WC, Kobes S, Bogardus C, Baier LJ. Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians. Diabetes. 2013;62(8):2984-91.
Related Scientific Focus Areas
This page was last updated on Wednesday, January 10, 2024