Alan Neil Schechter, M.D.
Molecular Medicine Branch
Building 10, Room 9N314B
10 Center Drive
Bethesda, MD 20814
Our research program is currently focused on the interaction of nitric oxide (NO) and hemoglobin, with the goal of understanding how NO may be transported by blood and thus act at distal sites, opening up its use as a pharmacological agent. This work has the potential for developing therapies for a variety of ischemic diseases, as well as sickle cell anemia and related hemoglobinopathies in which blood flow is impaired. Other research projects currently underway involve studies of the pathophysiological role of cell-free hemoglobin, cell signaling in the NO pathway, and the effects of nitrite/NO on platelet function.
Machha A, Schechter AN. Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables? Nutr Rev. 2012;70(6):367-72.
Srihirun S, Sriwantana T, Unchern S, Kittikool D, Noulsri E, Pattanapanyasat K, Fucharoen S, Piknova B, Schechter AN, Sibmooh N. Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation. PLoS One. 2012;7(1):e30380.
Piknova B, Kocharyan A, Schechter AN, Silva AC. The role of nitrite in neurovascular coupling. Brain Res. 2011;1407:62-8.
Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr. 2011;50(5):293-303.
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Res Cardiol. 2011;106(3):343-54.