Alan Neil Schechter, M.D.
Molecular Medicine Branch
Building 10, Room 9N314B
10 Center Drive
Bethesda, MD 20814
Studying the interaction of blood, especially red cells and hemoglobin, with the recently discovered signaling molecule nitric oxide (NO) should provide new information about normal and abnormal physiology and potential pharmacology.
Our research program is currently focused on the interaction of NO and hemoglobin, with the goal of understanding how NO may be transported by blood and thus act at distal sites, opening up its use as a pharmacological agent. This work has the potential for developing therapies for a variety of ischemic diseases, as well as sickle cell anemia and related hemoglobinopathies in which blood flow is impaired. Other research projects currently underway involve studies of the pathophysiological role of cell-free hemoglobin, cell signaling in the NO pathway, and the effects of nitrite/NO on platelet function.
Applying our Research
This research may give us clues regarding how to develop new therapies for several common diseases, as well as improve our understanding and treatment of the genetic anemias.
Need for Further Study
The control of blood flow in human beings, both normally and in disease states, requires further study.
- Special Research Fellow, NIAMS, NIH, 1967-1969
- Research Associate, NIAMS, NIH, 1965-1967
- Resident, Albert Einstein Medical College, 1963-1965
- M.D., Columbia University, 1963
- B.A., Cornell University, 1959
Park JW, Piknova B, Nghiem K, Lozier JN, Schechter AN. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide. 2014;40:45-51.
Park JW, Piknova B, Kurtz J, Seetharaman S, Wagner SJ, Schechter AN. Effect of storage on levels of nitric oxide metabolites in platelet preparations. Transfusion. 2013;53(3):637-44.
Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN. JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. J Transl Med. 2012;10:116.
Machha A, Schechter AN. Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables? Nutr Rev. 2012;70(6):367-72.
Srihirun S, Sriwantana T, Unchern S, Kittikool D, Noulsri E, Pattanapanyasat K, Fucharoen S, Piknova B, Schechter AN, Sibmooh N. Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation. PLoS One. 2012;7(1):e30380.