Wai T. Wong, M.D., Ph.D.

Investigator

Unit on Neuron-Glia Interactions in Retinal Disease

NEI

Building 6, Room 217
6 Center Drive
Bethesda, MD 20892-0606

301-496-7566

wongw@nei.nih.gov

Research Topics

Our research group, the Unit on Neuron-Glia Interactions in Retinal Diseases (UNGIRD), investigates the role of microglia, the resident immune cell of the retina, in normal physiological function and in the pathogenesis of retinal diseases. Of particular interest are retinal diseases in which age-related neuroinflammation features prominently, such as diabetic retinopathy and age-related macular degeneration (AMD), which are responsible for the majority of vision loss in the developed world. Key areas of focus are: 1) the role of microglia in the basic physiological function of the retina, and cell-cell interactions between microglia and other retinal cell types, 2) the aging phenotype of the retinal microglial cell, 3) the role of microglia in the pathogenesis of retinal disorders, and 4) translational research on microglial-based therapies in preclinical and proof-of-concept phase I/II clinical trials.

Our laboratory has used a combination of ex vivo live-imaging techniques, in vitro studies, and animal models of disease to investigate the involvement of microglia in intercellular interactions with other retinal cell types under normal and pathological conditions. One key motivation is to understand how these cellular interactions undergo progressive change during senescence, resulting in age-related neuroinflammation that drive retinal disease pathogenesis. We are interested in discovering the molecular bases for these cellular interactions which allow the discovery of therapeutic targets directed at retinal microglia. The group is currently involved in a number of phase I/II trials using microglial inhibition as a treatment for diabetic retinopathy and retinal vein occlusions.

Biography

Dr Wong received S.B degrees in Chemical Engineering and Biology from the Massachusetts Institute of Technology (M.I.T.) in 1994 and MD, PhD degrees from Washington University of Medicine in 2001. As an undergraduate, he worked in the laboratories of Dr. Rudolph Jaenisch in mouse genetics and Dr. Robert Langer in drug delivery devices. His graduate thesis under Dr Rachel Wong examined the role of neurotransmission in the developing retina in generating patterns of spontaneous retinal activity and remodeling retinal ganglion cell dendrites during the time of developmental synaptogenesis. He also performed postdoctoral work in the laboratory of Dr Jean Bennett studying the developmental role of PEDF using gene therapy techniques. He completed an ophthalmology residency program at the University of Pennsylvania in 2005, and a medical retina fellowship at the National Eye Institute under Dr Emily Chew in 2007. In 2007, he joined the Clinician Scientist Development Program at NEI and became a tenure track investigator in 2011. His laboratory, the Unit on Neuron-Glia Interactions in Retinal Diseases (UNGIRD), studies the role of microglia, the resident immune cell of the retina, in the pathogenesis of retinal diseases and the use of microglia-directed therapies. A board-certified ophthalmologist and a member of the Macula Society, Dr Wong specializes in diseases of the retina including age-related macular degeneration, diabetic retinopathy, and ocular von Hippel-Lindau disease.

Selected Publications

  1. Zabel MK, Zhao L, Zhang Y, Gonzalez SR, Ma W, Wang X, Fariss RN, Wong WT. Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa. Glia. 2016;64(9):1479-91.

  2. Zhao L, Zabel MK, Wang X, Ma W, Shah P, Fariss RN, Qian H, Parkhurst CN, Gan WB, Wong WT. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med. 2015;7(9):1179-97.

  3. Wang M, Wang X, Zhao L, Ma W, Rodriguez IR, Fariss RN, Wong WT. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J Neurosci. 2014;34(10):3793-806.

  4. Wang X, Zhao L, Zhang J, Fariss RN, Ma W, Kretschmer F, Wang M, Qian HH, Badea TC, Diamond JS, Gan WB, Roger JE, Wong WT. Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. J Neurosci. 2016;36(9):2827-42.

  5. Wang X, Zhao L, Zhang Y, Ma W, Gonzalez SR, Fan J, Kretschmer F, Badea TC, Qian HH, Wong WT. Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration. J Neurosci. 2017;37(12):3294-3310.


This page was last updated on July 31st, 2017