Wai T. Wong, M.D., Ph.D.
Neuron-Glia Interactions in Retinal Disease Section
Building 6, Room 217
6 Center Drive
Bethesda, MD 20892-0606
Our laboratory has used a combination of ex vivo live-imaging techniques, in vitro studies, and animal models of disease to investigate the involvement of microglia in intercellular interactions with other retinal cell types under normal and pathological conditions. One key motivation is to understand how these cellular interactions undergo progressive change during senescence, resulting in age-related neuroinflammation that drive retinal disease pathogenesis. We are interested in discovering the molecular bases for these cellular interactions which allow the discovery of therapeutic targets directed at retinal microglia. The group is currently involved in a number of phase I/II trials using microglial inhibition as a treatment for diabetic retinopathy and retinal vein occlusions.
Silverman SM, Wong WT. Microglia in the Retina: Roles in Development, Maturity, and Disease. Annu Rev Vis Sci. 2018.
Zhang Y, Zhao L, Wang X, Ma W, Lazere A, Qian HH, Zhang J, Abu-Asab M, Fariss RN, Roger JE, Wong WT. Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. Sci Adv. 2018;4(3):eaap8492.
Wang X, Zhao L, Zhang Y, Ma W, Gonzalez SR, Fan J, Kretschmer F, Badea TC, Qian HH, Wong WT. Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration. J Neurosci. 2017;37(12):3294-3310.
Wang X, Zhao L, Zhang J, Fariss RN, Ma W, Kretschmer F, Wang M, Qian HH, Badea TC, Diamond JS, Gan WB, Roger JE, Wong WT. Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. J Neurosci. 2016;36(9):2827-42.
Zhao L, Zabel MK, Wang X, Ma W, Shah P, Fariss RN, Qian H, Parkhurst CN, Gan WB, Wong WT. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med. 2015;7(9):1179-97.
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This page was last updated on August 20th, 2018