Thomas A. Fleisher, M.D.

Scientist Emeritus

Department of Laboratory Medicine

NIH Clinical Center

Building 10, Room 2C306
10 Center Drive
Bethesda, MD 20892


Research Topics

Dr. Fleisher's research interests focus on improving current assays and developing new diagnostic methods in laboratory immunology, particularly as they pertain to immune deficiency disorders. He is a member of a group of NIH medical scientists who described and characterized the autoimmune lymphoproliferative syndrome (ALPS), and more recently his laboratory defined the RAS associated autoimmune leukoproliferative disorder (RALD) as part of Dr. Fleisher's ongoing work in human immune dysregulation disorders. Fleisher served as the editor in chief of the Journal of Clinical Immunology from 2011-2012 and is on the editorial board of Current Opinion in Allergy and Clinical Immunology, Clinical and Laboratory Immunology, and Communications in Clinical Cytometry. He has been a co-editor of all four editions of the textbook Clinical Immunology: Principles and Practice: the fourth edition has a 2013 publication date. Dr. Fleisher has published more than 230 scientific papers, reviews, and chapters.


Dr. Fleisher received his medical and pediatric training at the University of Minnesota and went on for training in immunology at NIH in the laboratory of Dr. Thomas Waldmann. Following this training and a brief faculty position at Walter Reed Army Medical Center, he was chosen to direct the Clinical Immunology Laboratory in the Department of Laboratory Medicine at NIH. In 1998, he was selected as chief of the Department of Laboratory Medicine, where he also continues to run the Immunology Service within the department. He is an adjunct professor of pediatrics at Uniformed Services University of the Health Sciences, and serves as consultant to the Allergy Immunology Department at Walter Reed Military Medical Center. He served as a member of the board of directors of the American Board of Allergy and Immunology from 1991-2000 and was elected chair of the board in 1996. He also was a member of the American Board of Pediatrics from 1996-2001; the executive committee of the Clinical Immunology Society from 2003-2006, serving as its president in 2005; and the board of directors of the American Academy of Allergy, Asthma and Immunology from 2003-2007. He was President of the Robert A. Good Immunology Society from 2008-2010 and currently is a member of the Section on Allergy and Immunology Executive Committee of the American Academy of Pediatrics.

Selected Publications

  1. Price S, Shaw PA, Seitz A, Joshi G, Davis J, Niemela JE, Perkins K, Hornung RL, Folio L, Rosenberg PS, Puck JM, Hsu AP, Lo B, Pittaluga S, Jaffe ES, Fleisher TA, Rao VK, Lenardo MJ. Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations. Blood. 2014;123(13):1989-99.

  2. Kuehn HS, Niemela JE, Rangel-Santos A, Zhang M, Pittaluga S, Stoddard JL, Hussey AA, Evbuomwan MO, Priel DA, Kuhns DB, Park CL, Fleisher TA, Uzel G, Oliveira JB. Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans. Blood. 2013;121(16):3117-25.

  3. Niemela JE, Lu L, Fleisher TA, Davis J, Caminha I, Natter M, Beer LA, Dowdell KC, Pittaluga S, Raffeld M, Rao VK, Oliveira JB. Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. Blood. 2011;117(10):2883-6.

  4. Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, Schickel JN, Tran DQ, Stoddard J, Zhang Y, Frucht DM, Dumitriu B, Scheinberg P, Folio LR, Frein CA, Price S, Koh C, Heller T, Seroogy CM, Huttenlocher A, Rao VK, Su HC, Kleiner D, Notarangelo LD, Rampertaap Y, Olivier KN, McElwee J, Hughes J, Pittaluga S, Oliveira JB, Meffre E, Fleisher TA, Holland SM, Lenardo MJ, Tangye SG, Uzel G. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 2014;345(6204):1623-7.

  5. Calvo KR, Price S, Braylan RC, Oliveira JB, Lenardo M, Fleisher TA, Rao VK. JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities. Blood. 2015;125(18):2753-8.

This page was last updated on June 5th, 2018