Steven J. Sollott, M.D.

We are studying structure and function of cells and mitochondria from the cardiovascular system along two principal and distinct lines: 1) control mechanisms for matching ATP supply and demand in heart mitochondria, with a major focus on discovery of novel and fundamental properties of ATP synthase, 2) mechanisms of protection of the myocardium against injury, especially from that of ischemia-reperfusion. Two additional area that had been primary interests of the Section in the past are pursued now as secondary research objectives when they meaningfully support the principal lines above: 3) mechanisms of cardiac contractility, and 4) cellular changes after vascular injury. An underlying theme in each of these areas involves the pursuit and development of single cell, subcellular and single-molecule biophysical methods to overcome certain limitations and complexities inherent in in vivo and in multicellular in vitro experimental systems, to gain an understanding of basic cell biological processes that may have implications for the pathophysiology and treatment of human disease, and its relevance for aging.

Dr. Sollott received his M.D. from the University of Rochester and completed his residency in internal medicine at a Cornell University program. He subsequently completed his cardiology fellowship at Johns Hopkins University and an NIH medical staff fellowship at NIA's Laboratory of Cardiovascular Science. His research attempts to bridge interests spanning basic and clinical science to therapeutics.