Richard D. Fields, Ph.D.
Section on Nervous System Development and Plasticity
Nervous System Development and Plasticity
Our research is concerned with understanding the molecular and cellular mechanisms by which activity in the brain regulates development of the nervous system during late stages of fetal development and early postnatal life. This work has three main areas of emphasis. 1) We investigate how neurons and non-neuronal cells (glia) interact, communicate, and cooperate functionally. A major emphasis of this research is to understand how myelin (white matter in the brain) is regulated by functional activity, which could implicate myelin in learning, cognition, child development, and psychiatric disorders. The research is exploring how glia sense neural impulse activity at synapses and non-synaptic regions and the functional and developmental consequences of activity-dependent regulation of neurons and glia. 2) We are determining how different patterns of neural impulses regulate specific genes controlling development and plasticity of the nervous system. This includes effects of impulse activity on neurons and glia and the molecular signaling pathways regulating gene expression in these cells in response to neural impulses. 3) We aim to determine the molecular mechanisms converting short-term memory into long-term memory, and in particular, how gene expression necessary for long-term memory is controlled. We use cellular, molecular, and electrophysiological, methods in primary cell culture, hippocampal brain slices, and in vivo two-photon imaging.
R. Douglas Fields, Ph.D., is Chief of the Section on Nervous System Development and Plasticity in the NICHD. His long-standing interest is in nervous system plasticity and in particular the cellular mechanisms by which functional activity in the nervous system affects development and learning. This includes not only synaptic development and function, but also interactions between neurons and glia (non-neuronal brain cells), and regulation of myelin by impulse activity in axons. Before joining the NIH in 1987, Dr. Fields was a postdoctoral fellow at Yale University and Stanford University. He received his B.A. from the University of California, Berkeley, in 1975, an M.A. degree from San Jose State University in 1979, and a Ph.D. degree from the University of California, San Diego in 1985 for research performed jointly in the neuroscience program and Scripps Institution of Oceanography.
Dutta DJ, Woo DH, Lee PR, Pajevic S, Bukalo O, Huffman WC, Wake H, Basser PJ, SheikhBahaei S, Lazarevic V, Smith JC, Fields RD. Regulation of myelin structure and conduction velocity by perinodal astrocytes. Proc Natl Acad Sci U S A. 2018;115(46):11832-11837.
Wake H, Lee PR, Fields RD. Control of local protein synthesis and initial events in myelination by action potentials. Science. 2011;333(6049):1647-51.
Lee PR, Cohen JE, Iacobas DA, Iacobas S, Fields RD. Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons. Sci Rep. 2017;7:43765.
Wake H, Ortiz FC, Woo DH, Lee PR, Angulo MC, Fields RD. Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons. Nat Commun. 2015;6:7844.
Fields RD. A new mechanism of nervous system plasticity: activity-dependent myelination. Nat Rev Neurosci. 2015;16(12):756-67.
Related Scientific Focus Areas
Genetics and Genomics
Molecular Biology and Biochemistry
This page was last updated on November 15th, 2019