Marvin C. Gershengorn, M.D.
Laboratory of Endocrinology and Receptor Biology
Building 50, Room 4134
50 South Drive
Bethesda, MD 20814
To discover and develop probes or drugs for receptors for thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH).
I conduct studies on the structure-function relationships of G protein-coupled receptors—in particular, receptors for thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH). An important aspect of this research is to discover small molecule ligands for these receptors that can be used as probes in animal models and that can lead to the development of drugs for the treatment of endocrine and neurologic diseases in humans.
Applying our Research
This research may allow us to discover and develop drugs to treat several diseases of the thyroid gland including thyroid cancer, Graves’ hyperthyroidism, and ophthalmopathy. It will also allow us to discover and develop drugs to treat several neurologic diseases including narcolepsy, depression, and cancer-related fatigue.
Need for Further Study
Small molecule drug-like ligands for these receptors are not available.
- Abby Rockefeller Mauzé Distinguished Professor of Endocrinology in Medicine, Cornell University Medical College, 1983–2001
- Chief of the Division of Endocrinology and Metabolism, Cornell University Medical College, 1983–2001
- Professor of Medicine and Cell Biology and Genetics, Cornell University Medical College, 1983–2001
- Assistant and Associate Professor, New York University School of Medicine, 1976–1983
- M.D., New York University School of Medicine, 1971
- B.S., City College of the City University of New York, 1967
Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC. A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts. Thyroid. 2012;22(8):839-43.
Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence. Thyroid. 2011;21(8):907-12.
Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011;96(2):548-54.
Krieger CC, Neumann S, Place RF, Marcus-Samuels B, Gershengorn MC. Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobins. J Clin Endocrinol Metab. 2015;100(3):1071-7.
Related Scientific Focus Areas
This page was last updated on May 18th, 2016