Marvin C. Gershengorn, M.D.

Senior Investigator

Laboratory of Endocrinology and Receptor Biology

NIDDK

Building 50, Room 4134
50 South Drive
Bethesda, MD 20814

301-451-6305

marving@mail.nih.gov

Research Topics

Research Goal

To discover and develop probes or drugs for receptors for thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH).

Current Research

I conduct studies on the structure-function relationships of G protein-coupled receptors—in particular, receptors for thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH).  An important aspect of this research is to discover small molecule ligands for these receptors that can be used as probes in animal models and that can lead to the development of drugs for the treatment of endocrine and neurologic diseases in humans.​

Applying our Research

This research may allow us to discover and develop drugs to treat several diseases of the thyroid gland including thyroid cancer, Graves’ hyperthyroidism, and ophthalmopathy. It will also allow us to discover and develop drugs to treat several neurologic diseases including narcolepsy, depression, and cancer-related fatigue.

Need for Further Study

Small molecule drug-like ligands for these receptors are not available.

Biography

  • Abby Rockefeller Mauzé Distinguished Professor of Endocrinology in Medicine, Cornell University Medical College, 1983–2001
  • Chief of the Division of Endocrinology and Metabolism, Cornell University Medical College, 1983–2001
  • Professor of Medicine and Cell Biology and Genetics, Cornell University Medical College, 1983–2001
  • Assistant and Associate Professor, New York University School of Medicine, 1976–1983
  • M.D., New York University School of Medicine, 1971
  • B.S., City College of the City University of New York, 1967

Selected Publications

  1. Boutin A, Eliseeva E, Gershengorn MC, Neumann S. β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. FASEB J. 2014;28(8):3446-55.

  2. Katz LS, Geras-Raaka E, Gershengorn MC. Heritability of fat accumulation in white adipocytes. Am J Physiol Endocrinol Metab. 2014;307(3):E335-44.

  3. Hiram-Bab S, Katz LS, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol. 2014;229(6):743-51.

  4. Krieger CC, Gershengorn MC. A modified ELISA accurately measures secretion of high molecular weight hyaluronan (HA) by Graves' disease orbital cells. Endocrinology. 2014;155(2):627-34.

  5. Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014;155(1):310-4.

Related Scientific Focus Areas


This page was last updated on May 18th, 2016