Leonardo Belluscio, Ph.D.
Developmental Neural Plasticity Section
Building 35, Room 3A-116
35 Convent Drive
Bethesda, MD 20892-3703
My Laboratory conducts research to understand the principles and mechanisms that underlie neural plasticity and regeneration in the brain. Using the mammalian olfactory system as a model the laboratory focuses on four main goals: (1) identification of neural circuits within the olfactory system that exhibit functional plasticity; (2) determining the molecular and functional mechanisms that govern olfactory based plasticity; (3) understanding the relationship between plasticity and the capacity for repair of olfactory circuits; and (4) establishing the role of sensory induced activity on the restoration of neural circuits. Our research is multidisciplinary including biochemistry, molecular biology and electrophysiology as well as in vivo imaging, optogenetic and behavioral techniques all combined with genetically engineered mice. Given the connection between olfactory dysfunction and neurological disease such as Alzheimer's disease and Parkinson's disease, this work also has a strong translational focus.
Cheetham CE, Park U, Belluscio L. Rapid and continuous activity-dependent plasticity of olfactory sensory input. Nat Commun. 2016;7:10729.
Cheng N, Jiao S, Gumaste A, Bai L, Belluscio L. APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway. eNeuro. 2016;3(4).
Cummings DM, Snyder JS, Brewer M, Cameron HA, Belluscio L. Adult neurogenesis is necessary to refine and maintain circuit specificity. J Neurosci. 2014;34(41):13801-10.
Saar G, Cheng N, Belluscio L, Koretsky AP. Laminar specific detection of APP induced neurodegeneration and recovery using MEMRI in an olfactory based Alzheimer's disease mouse model. Neuroimage. 2015;118:183-92.
Zhou Z, Belluscio L. Coding odorant concentration through activation timing between the medial and lateral olfactory bulb. Cell Rep. 2012;2(5):1143-50.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on May 2nd, 2017