Lance M. Optican, Ph.D.

Senior Investigator

Neural Modeling Section

NEI

Building 49, Room 2A50
49 Convent Drive
Bethesda, MD 20892

301-496-9375

lmo@lsr.nei.nih.gov

Research Topics

Control of rapid gaze movements involves many parts of the brain, including cerebral, cerebellar, midbrain, basal ganglia and brain stem areas. The successful coordination of these areas is required for correct behavior under normal and adaptive conditions. When this coordination fails, clinical eye movement disorders develop. Our group builds neuromimetic models that function like the brain, from the biophysics of individual neurons to the networks across multiple brain areas. We also model the properties of passive and active extraocular eye muscles, as these are central to some disorders, such as strabismus (the misalignment of the two eyes). Our goal is to be able to understand the neuronal and muscular mechanisms underlying clinical eye movement disorders well enough to predict the effects of surgical and pharmaceutical therapies. Finally, our lab also looks at perception and action, relating eye movements and what we perceive in the world.

Biography

Dr. Optican received a B.Sc. degree from the California Institute of Technology in 1972, and a Ph.D. degree in Biomedical Engineering from the Johns Hopkins School of Medicine in 1978. His thesis work with Professor David A. Robinson was on the adaptive control of saccadic eye movements by the cerebellum. He then did a post-doctoral fellowship at NIMH with Dr. F. A. Miles, during which he studied visual influences on adaptive control of saccades. In 1979 Dr. Optican joined the NEI, and in 1985 he became chief of the Section on Neural Modeling in the Laboratory of Sensorimotor Research. His laboratory focuses on experimental and theoretical studies of sensory and motor aspects of normal, adaptive and impaired rapid eye and head movements.

Selected Publications

  1. Otero-Millan J, Optican LM, Macknik SL, Martinez-Conde S. Modeling the Triggering of Saccades, Microsaccades, and Saccadic Intrusions. Front Neurol. 2018;9:346.

  2. Pretegiani E, Rosini F, Rocchi R, Ginanneschi F, Vinciguerra C, Optican LM, Rufa A. GABAAergic dysfunction in the olivary-cerebellar-brainstem network may cause eye oscillations and body tremor. Clin Neurophysiol. 2017;128(3):408-410.

  3. Optican LM, Pretegiani E. A GABAergic Dysfunction in the Olivary-Cerebellar-Brainstem Network May Cause Eye Oscillations and Body Tremor. II. Model Simulations of Saccadic Eye Oscillations. Front Neurol. 2017;8:372.

  4. Daye PM, Optican LM, Blohm G, Lefèvre P. Hierarchical control of two-dimensional gaze saccades. J Comput Neurosci. 2014;36(3):355-82.

  5. Quaia C, Ying HS, Optican LM. The viscoelastic properties of passive eye muscle in primates. III: force elicited by natural elongations. PLoS One. 2010;5(3):e9595.


This page was last updated on August 24th, 2018