Jyoti Sen, M.Sc., Ph.D.

Senior Investigator

Immune Cells and Inflammation Section


251 Bayview Boulevard
Suite 100
Baltimore, MD 21224



Research Topics

Research in our laboratory focuses on the study of immunity, autoimmunity and inflammation. In particular, the development of conventional and innate immune cells in the thymus and the generation of gut-associated immune cells and the micro biome. We are also interested in understanding changes in gut-associated immune cells and the micro biome that may lead to systemic inflammation in older people.

Ongoing projects include:

  1. Study of transcription factors that regulate the development, maintenance and aging of thymic lymphocytes as well as epithelial cells.
  2. Development and function of conventional and innate like immune cells in the thymus.
  3. Development and age-associated changes in gut-associated immune cells and the micro biome.


Dr. Misra Sen earned her M.Sc. in Chemistry from Indian Institute of Technology at Kanpur and Ph. D. in Biological Sciences from Columbia University in New York City. After completing David Abraham Fellowship at Dana Farber Cancer Institute she was named Claudia Adams Barr Investigator with faculty appointments at Dana Farber Cancer Institute and Harvard Medical School. Her work was funded by grants from The Barr Foundation, The Arthritis Foundation and NCI-NIH. She moved to the NIA-NIH in 2003.

Selected Publications

  1. Berga-Bolaños R, Sharma A, Steinke FC, Pyaram K, Kim YH, Sultana DA, Fang JX, Chang CH, Xue HH, Heller NM, Sen JM. β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation. BMC Immunol. 2015;16:62.

  2. Prevot N, Pyaram K, Bischoff E, Sen JM, Powell JD, Chang CH. Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger. J Immunol. 2015;194(1):223-30.

  3. Sharma A, Chen Q, Nguyen T, Yu Q, Sen JM. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188(8):3859-68.

  4. Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009;10(9):992-9.

  5. Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL. TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Rep. 2015;12(12):2099-110.

This page was last updated on August 16th, 2017