Jyoti Sen, M.Sc., Ph.D.

Senior Investigator

Immune Cells and Inflammation Section


251 Bayview Boulevard
Suite 100
Baltimore, MD 21224



Research Topics

Research in our laboratory focuses on the study of immunity, autoimmunity and inflammation. In particular, we are interested in understanding the role of peripheral, brain associated and gut-associated immune cells, as well as the gut-microbiota in the development of age-related chronic systemic inflammation and age-related neurological ailments including EAE, Parkinson's and Alzheimer's disease.

Ongoing projects include:

  1. Study of transcription factors that regulate the development, maintenance and aging of conventional and innate immune cells.
  2. Study of innate and adaptive immune cells in chronic neurological diseases, including EAE, Parkinson's and Alzheimer's disease.
  3. Age-associated systemic inflammation and its role in chronic neurological diseases.


Dr. Sen earned her M.Sc. in Chemistry from Indian Institute of Technology at Kanpur and Ph. D. in Biological Sciences from Columbia University in New York City. After completing David Abraham Fellowship at Dana Farber Cancer Institute, she was named Claudia Adams Barr Investigator with faculty appointments at Dana Farber Cancer Institute and Harvard Medical School. Her work was funded by grants from The Barr Foundation, The Arthritis Foundation and NCI-NIH. She was recruited to the NIA-NIH in 2003.

Selected Publications

  1. Berga-Bolaños R, Sharma A, Steinke FC, Pyaram K, Kim YH, Sultana DA, Fang JX, Chang CH, Xue HH, Heller NM, Sen JM. β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation. BMC Immunol. 2015;16:62.

  2. Prevot N, Pyaram K, Bischoff E, Sen JM, Powell JD, Chang CH. Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger. J Immunol. 2015;194(1):223-30.

  3. Sharma A, Chen Q, Nguyen T, Yu Q, Sen JM. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188(8):3859-68.

  4. Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009;10(9):992-9.

  5. Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL. TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Rep. 2015;12(12):2099-110.

This page was last updated on August 22nd, 2019