Jonathan Joseph Lyons, M.D.

Assistant Clinical Investigator

Genetics and Pathogenesis of Allergy Section


10 Center Drive
Bulding 10
Room 11N240, Bethesda, MD 20814


Research Topics

Working in the Milner lab since 2014, Dr. Lyons has been involved in the identification of novel genetic causes for allergic inflammation and immune dysregulation. These include phosphoglucomutase 3 (PGM3) deficiency, an autosomal recessive congenital disorder of glycosylation that leads to a complex hyper-IgE phenotype, and tryptasemia, a variably penetrant disorder associated with dominantly inherited elevations in basal serum tryptase. Deciphering how changes in glycosylation may lead to atopy and immune dysregulation and affect allergic reactions is currently a major area of focus. A second area of focus is on the role that isoforms of the glycoprotein tryptase may play on influencing clinical phenotypes and allergic reactions.


Jonathan Lyons received his undergraduate education at Pomona College and Jesus College, Cambridge, United Kingdon, where he spent two terms. He graduated with a B.A. in chemistry from Pomona College in 2003 and received an M.D. from the University of Southern California in 2007. Dr. Lyons completed residency training in internal medicine at the University of California, San Diego, in 2010, remaining an additional year as a chief medical resident. He concluded his formal medical training in 2014 at NIAID as a clinical fellow in allergy and immunology. Following completion of a fellowship, he was selected for the NIAID Transition Program in Clinical Research and is currently an assistant clinical investigator in the Laboratory of Allergic Diseases. Dr. Lyons is board certified in internal medicine and allergy/immunology, a member of the Clinical Immunology Society, and a member of the American Academy of Allergy, Asthma & Immunology, where he serves on the Genetics, Molecular Biology, and Epidemiology Committee. He is an associate investigator on several clinical protocols and the principle investigator on a protocol to provide sugar supplementation to patients with glycosylation defects and immunologic disease.


Selected Publications

  1. Carlson RJ, Bond MR, Hutchins S, Brown Y, Wolfe LA, Lam C, Nelson C, DiMaggio T, Jones N, Rosenzweig SD, Stone KD, Freeman AF, Holland SM, Hanover JA, Milner JD, Lyons JJ. Detection of phosphoglucomutase-3 deficiency by lectin-based flow cytometry. J Allergy Clin Immunol. 2017;140(1):291-294.e4.

  2. Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD. ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans. J Exp Med. 2017;214(3):669-680.

  3. Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti F, Rings EH, Thrasher AJ, Milner JD, Snapper SB, Fiebiger E. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016;126(10):4030-4044.

  4. Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016;48(12):1564-1569.

  5. Lyons JJ, Sun G, Stone KD, Nelson C, Wisch L, O'Brien M, Jones N, Lindsley A, Komarow HD, Bai Y, Scott LM, Cantave D, Maric I, Abonia JP, Rothenberg ME, Schwartz LB, Milner JD, Wilson TM. Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol. 2014;133(5):1471-4.

This page was last updated on August 3rd, 2017