John Spouge, M.D., Ph.D.

Senior Investigator

Statistical Computational Biology Group


Building 38A, Room 6N603
8600 Rockville Pike
Bethesda, MD 20894


Research Topics

After experience elsewhere in the classical modeling of physical, chemical, and biological systems, particularly HIV infectivity assays, Dr. Spouge's research at NCBI has focused on sequence alignment and sequence structure statistics, with particular application to BLAST statistics and the detection of transcription binding factor motifs. Recently, he has contributed to the international effort to identify species with DNA barcodes, a field with applications to the conservation of species, the control of poaching, the protection against pests at customs, and the detection of consumer fraud by species substitution. Dr. Spouge's special interest is formulating and solving difficult mathematical problems that have important biological applications.


Dr. Spouge graduated from the University of British Columbia with a B.Sc. in Mathematics and an M.D., before obtaining a D. Phil. in Mathematics under John Hammersley at the University of Oxford. After a two-year post-doctoral fellowship at Los Alamos National Laboratory in T-10, the Theoretical Biology group, he came to the National Cancer Institute in 1985, and from there, to the National Center for Biotechnology Information (NCBI) in 1989.

Related Scientific Focus Areas

This page was last updated on Monday, August 28, 2023