Harvey G. Klein, M.D.

Senior Investigator

Transfusion Medicine Department

NIH Clinical Center

Building 10, Room 1C711
10 Center Drive
Bethesda, MD 20892



Research Topics

Dr. Klein is known nationally and internationally for his expertise in blood transfusion. He is widely published on such topics as transfusion-transmitted disease, adverse effects of blood transfusion, and the impact of biotechnology on transfusion medicine. He co-authored the eleventh edition of Mollison's textbook, Blood Transfusion in Clinical Medicine, and has held editorial roles with several publications, including Blood, Transfusion, Transfusion Medicine Review, and the Journal of Clinical Apheresis. He has an extensive list of professional activities that includes serving on the Institute of Medicine Blood Safety Forum, the Secretary's Advisory Committee on Blood Safety and Availability, the WHO Committee on Standardization, and the FDA Blood Products Advisory Committee; chairing the US Pharmacopoeia Blood and Blood Products Committee and the American Red Cross Medical Advisory Committee; and serving as president of the American Association of Blood Banks and the National Marrow Donor Program Council.


Dr. Klein graduated magna cum laude from Harvard College and earned his medical degree from Johns Hopkins School of Medicine. After an internship, residency and fellowship in hematology at Hopkins, he came to the National Institutes of Health in 1973, becoming chief of the Clinical Center's Department of Transfusion Medicine in 1983. He maintains his ties with Hopkins as a visiting professor in pathology and medicine.

Selected Publications

  1. Klein HG, Garner RJ, Miller DM, Rosen SL, Statham NJ, Winslow RM. Automated partial exchange transfusion in sickle cell anemia. Transfusion. 1980;20(5):578-84.
  2. Lane HC, Masur H, Longo DL, Klein HG, Rook AH, Quinnan GV Jr, Steis RG, Macher A, Whalen G, Edgar LC. Partial immune reconstitution in a patient with the acquired immunodeficiency syndrome. N Engl J Med. 1984;311(17):1099-103.
  3. Blaese RM, Culver KW, Miller AD, Carter CS, Fleisher T, Clerici M, Shearer G, Chang L, Chiang Y, Tolstoshev P, Greenblatt JJ, Rosenberg SA, Klein H, Berger M, Mullen CA, Ramsey WJ, Muul L, Morgan RA, Anderson WF. T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science. 1995;270(5235):475-80.
  4. Walker RE, Carter CS, Muul L, Natarajan V, Herpin BR, Leitman SF, Klein HG, Mullen CA, Metcalf JA, Baseler M, Falloon J, Davey RT Jr, Kovacs JA, Polis MA, Masur H, Blaese RM, Lane HC. Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. Nat Med. 1998;4(7):852-6.
  5. Solomon SB, Wang D, Sun J, Kanias T, Feng J, Helms CC, Solomon MA, Alimchandani M, Quezado M, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013;121(9):1663-72.

Related Scientific Focus Areas

This page was last updated on Wednesday, May 1, 2013