G. Marius Clore, M.D., Ph.D.

NIH Distinguished Investigator

Section of Molecular and Structural Biophysics, Laboratory of Chemical Physics

NIDDK

Building NIHBC 05, Room B1-30I
5 Memorial Dr
Bethesda, MD 20892

+1 301 496 0782

mariusc@intra.niddk.nih.gov

Research Topics

The purpose of my lab’s research is to understand the interrelationship between the structure, dynamics, and function of proteins. A particular focus is the study of rare, highly transient, “excited” states of proteins and their complexes that play a key role of molecular recognition.

Current Research

Our lab studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and we develop and apply novel NMR and computational methods to aid in these studies. We are particularly interested in complexes involved in signal transduction and transcriptional regulation, and on AIDS and AIDS-related proteins. More recently we have focused on the development of novel NMR methods to detect, visualize, and characterize transient, sparsely-populated states of macromolecules. Such states, which are invisible to conventional biophysical techniques, including crystallography, play a critical role in macromolecular recognition, allostery induced fit, conformational selection, and molecular assembly. Dr. Clore is a Fellow of the Royal Society, a Member of the National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, and a Foreign Member of the Academia Europaea. Prizes and awards include the Royal Society of Chemistry Centenary and Khorana Prizes, the Biochemical Society (U.K.) Centenary Award, The Biophysical Society Innovation Award, and the Biopolymers Murray Goodman Memorial Prize.

Applying our Research

This research will facilitate targeted and rational drug design.

Biography

  • NIH Distinguished Investigator, NIDDK, NIH (2011-present)
  • NIH Senior Investigator, NIDDK, NIH, 1988-present
  • Head, Biological NMR Group, Max Planck Institute for Biochemistry, Martinsried, Germany, 1984-1988
  • Member of Scientific Staff, MRC National Institute for Medical Research, London, U.K., 1980-1984
  • House Surgeon, St. Charles Hospital (St. Mary's Group), 1980
  • House Physician, University College Hospital, 1979-1980
  • Ph.D., MRC National Institute for Medical Research, London, 1982
  • M.D., University College hospital Medical School London, 1979
  • B.Sc. (1st class honors), University College, London, 1976

Selected Publications

  1. Schmidt T, Jeon J, Yau WM, Schwieters CD, Tycko R, Clore GM. Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca2+-ligated calmodulin. Proc Natl Acad Sci U S A. 2022;119(6).
  2. Ceccon A, Tugarinov V, Ghirlando R, Clore GM. Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I. Proc Natl Acad Sci U S A. 2020;117(11):5844-5852.
  3. Kotler SA, Tugarinov V, Schmidt T, Ceccon A, Libich DS, Ghirlando R, Schwieters CD, Clore GM. Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR. Proc Natl Acad Sci U S A. 2019;116(9):3562-3571.
  4. Karamanos TK, Tugarinov V, Clore GM. Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis. Proc Natl Acad Sci U S A. 2019;116(43):21529-21538.

Related Scientific Focus Areas

This page was last updated on Monday, December 5, 2022