G. Marius Clore, M.D., Ph.D.
NIH Distinguished Investigator
Protein Nuclear Magnetic Resonance Section, Laboratory of Chemical Physics
Building 5, Room B130
5 Memorial Drive
Bethesda, MD 20814
The purpose of my lab’s research is to understand the interrelationship between the structure, dynamics, and function of proteins.
Our lab studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and we develop and apply novel NMR and computational methods to aid in these studies. We are particularly interested in complexes involved in signal transduction and transcriptional regulation, and on AIDS and AIDS-related proteins. More recently we have focused on the development of novel NMR methods to detect, visualize, and characterize transient, sparsely populated states of macromolecules. Such states, which are invisible to conventional biophysical techniques, including crystallography, play a critical role in macromolecular recognition, allostery induced fit, conformational selection, and molecular assembly. Dr. Clore is an elected member of the National Academy of Sciences, the American Academy of Arts and Sciences and Academia Europaea.
Applying our Research
This research will facilitate targeted and rational drug design.
- NIH Investigator, NIDDK, NIH, 1988 - present
- Head, Biological NMR Group, Max Planck Institute for Biochemistry, Martinsried, Germany, 1984-1988
- Member of Scientific Staff, MRC National Institute for Medical Research, London, U.K., 1980-1984
- House Surgeon, St Charles Hospital (St. Mary's Group), 1980
- House Physician, University College Hospital, 1979-1980
- Ph.D., MRC National Institute for Medical Research, London, 1982
- M.D., University College Hospital Medical School, London, 1979
- B.Sc. (1st class honors), University College London, 1976
Schmidt T, Wälti MA, Baber JL, Hustedt EJ, Clore GM. Long Distance Measurements up to 160 Å in the GroEL Tetradecamer Using Q-Band DEER EPR Spectroscopy. Angew Chem Int Ed Engl. 2016;55(51):15905-15909.
Fawzi NL, Ying J, Ghirlando R, Torchia DA, Clore GM. Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature. 2011;480(7376):268-72.
Venditti V, Egner TK, Clore GM. Hybrid Approaches to Structural Characterization of Conformational Ensembles of Complex Macromolecular Systems Combining NMR Residual Dipolar Couplings and Solution X-ray Scattering. Chem Rev. 2016;116(11):6305-22.
Deshmukh L, Louis JM, Ghirlando R, Clore GM. Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations. Proc Natl Acad Sci U S A. 2016;113(44):12456-12461.
Ceccon A, Tugarinov V, Bax A, Clore GM. Global Dynamics and Exchange Kinetics of a Protein on the Surface of Nanoparticles Revealed by Relaxation-Based Solution NMR Spectroscopy. J Am Chem Soc. 2016;138(18):5789-92.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
This page was last updated on September 14th, 2017