David Schlessigner, Ph.D.

NIH Distinguished Investigator

Laboratory of Genetics


251 Bayview Boulevard
Suite 100
Baltimore, MD 21224



Research Topics

The Human Genetics Section The program is designed to study embryonic and developmental events critical for the aging of specialized mammalian cells and concomitant aging-related phenomena.


Dr. Schlessinger received his Ph.D. from Harvard University in 1960. Following postdoctoral training at the Pasteur Institute in Paris, he joined Washington University in St. Louis, where he served as Professor of Molecular Microbiology, Genetics, and Microbiology in Medicine until his move to NIA in September, 1997. He has contributed both to microbial and human genome studies. He has served as President of the American Society for Microbiology in 1995, and as the Director of the Human Genome Center at Washington University from 1987-97. During his tenure as Center director, he oversaw the development of the X chromosome map and of much related technology, with the concomitant finding of a number of disease genes. He is currently a councillor of the Human Genome Organization (HUGO) International, and President, HUGO Americas.

Selected Publications

  1. Ding J, Sidore C, Butler TJ, Wing MK, Qian Y, Meirelles O, Busonero F, Tsoi LC, Maschio A, Angius A, Kang HM, Nagaraja R, Cucca F, Abecasis GR, Schlessinger D. Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools. PLoS Genet. 2015;11(7):e1005306.

  2. Pelosi E, Simonsick E, Forabosco A, Garcia-Ortiz JE, Schlessinger D. Dynamics of the ovarian reserve and impact of genetic and epidemiological factors on age of menopause. Biol Reprod. 2015;92(5):130.

  3. Cui CY, Ishii R, Campbell DP, Michel M, Piao Y, Kume T, Schlessinger D. Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder. J Invest Dermatol. 2017;137(1):38-45.

  4. Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, Lai S, Marongiu M, Serra V, Marongiu M, Sole G, Busonero F, Maschio A, Cusano R, Cuccuru G, Deidda F, Poddie F, Farina G, Dei M, Virdis F, Olla S, Satta MA, Pani M, Delitala A, Cocco E, Frau J, Coghe G, Lorefice L, Fenu G, Ferrigno P, Ban M, Barizzone N, Leone M, Guerini FR, Piga M, Firinu D, Kockum I, Lima Bomfim I, Olsson T, Alfredsson L, Suarez A, Carreira PE, Castillo-Palma MJ, Marcus JH, Congia M, Angius A, Melis M, Gonzalez A, Alarcón Riquelme ME, da Silva BM, Marchini M, Danieli MG, Del Giacco S, Mathieu A, Pani A, Montgomery SB, Rosati G, Hillert J, Sawcer S, D'Alfonso S, Todd JA, Novembre J, Abecasis GR, Whalen MB, Marrosu MG, Meloni A, Sanna S, Gorospe M, Schlessinger D, Fiorillo E, Zoledziewska M, Cucca F. Overexpression of the Cytokine BAFF and Autoimmunity Risk. N Engl J Med. 2017;376(17):1615-1626.

  5. Pelosi E, Omari S, Michel M, Ding J, Amano T, Forabosco A, Schlessinger D, Ottolenghi C. Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice. Nat Commun. 2013;4:1843.

This page was last updated on August 23rd, 2017