David Schlessigner, Ph.D.

NIH Distinguished Investigator

Laboratory of Genetics


251 Bayview Boulevard
Suite 100
Baltimore, MD 21224



Research Topics

The Human Genetics Section The program is designed to study embryonic and developmental events critical for the aging of specialized mammalian cells and concomitant aging-related phenomena.


Dr. Schlessinger received his Ph.D. from Harvard University in 1960. Following postdoctoral training at the Pasteur Institute in Paris, he joined Washington University in St. Louis, where he served as Professor of Molecular Microbiology, Genetics, and Microbiology in Medicine until his move to NIA in September, 1997. He has contributed both to microbial and human genome studies. He has served as President of the American Society for Microbiology in 1995, and as the Director of the Human Genome Center at Washington University from 1987-97. During his tenure as Center director, he oversaw the development of the X chromosome map and of much related technology, with the concomitant finding of a number of disease genes. He is currently a councillor of the Human Genome Organization (HUGO) International, and President, HUGO Americas.

Selected Publications

  1. Ding J, Sidore C, Butler TJ, Wing MK, Qian Y, Meirelles O, Busonero F, Tsoi LC, Maschio A, Angius A, Kang HM, Nagaraja R, Cucca F, Abecasis GR, Schlessinger D. Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools. PLoS Genet. 2015;11(7):e1005306.

  2. Cui CY, Schlessinger D. Eccrine sweat gland development and sweat secretion. Exp Dermatol. 2015;24(9):644-50.

  3. Pistis G, Porcu E, Vrieze SI, Sidore C, Steri M, Danjou F, Busonero F, Mulas A, Zoledziewska M, Maschio A, Brennan C, Lai S, Miller MB, Marcelli M, Urru MF, Pitzalis M, Lyons RH, Kang HM, Jones CM, Angius A, Iacono WG, Schlessinger D, McGue M, Cucca F, Abecasis GR, Sanna S. Rare variant genotype imputation with thousands of study-specific whole-genome sequences: implications for cost-effective study designs. Eur J Hum Genet. 2015;23(7):975-83.

  4. Pelosi E, Simonsick E, Forabosco A, Garcia-Ortiz JE, Schlessinger D. Dynamics of the ovarian reserve and impact of genetic and epidemiological factors on age of menopause. Biol Reprod. 2015;92(5):130.

This page was last updated on July 17th, 2017