David K. Henderson, M.D.

Senior Investigator

Office of the Director

NIH Clinical Center

Building 10, Room 6-2551
10 Center Drive
Bethesda, MD 20892



Research Topics

Dr. David Henderson is Deputy Director for Clinical Care and Associate Director for Quality Assurance and Hospital Epidemiology at the NIH Clinical Center. He first came to NIH in 1979 as the hospital epidemiologist, a position he still holds. His research focuses on the risks of occupational and healthcare-associated infection with bloodborne infectious diseases, and the threat of emerging and antimicrobial-resistant infections to public health. His work has contributed to our understanding of the occupational risks associated with exposure to bloodborne pathogens in the healthcare workplace as well as primary and secondary prevention strategies effective in mitigating those risks.

In 2010, to honor his career contributions to healthcare epidemiology, he was selected by the Society of Healthcare Epidemiology in America (SHEA) as the SHEA Lecturer for the 5th International Decennial Conference on Nosocomial Infections. In 2005 he was named NIH Liaison to the DHHS Secretary's Healthcare Infection Control Policy Advisory Committee (HICPAC). An invited speaker internationally, Dr. Henderson also is a frequent invited consultant to the Centers for Disease Control and Prevention. He has published more than 135 peer-reviewed journal articles as well as dozens of book chapters. His membership in medical organizations focuses on those with involvement in infectious diseases and epidemiology. He was selected as the initial Chair of the SHEA Research Committee. In 2009 he was named to the DHHS Secretary's Steering Committee for the Prevention of Healthcare Associated Infections.


After earning his medical degree from the University of Chicago's Pritzker School of Medicine, Dr. Henderson completed an internship and residency in internal medicine and a two-year fellowship in infectious diseases at Harbor-UCLA (University of California at Los Angeles) Medical Center. Subsequently, he was assistant professor of medicine at UCLA School of Medicine. He has received six NIH Director's Awards, a Clinical Center Director's Award, two Director's Merit Awards for Significant Achievement from the National Institute of Mental Health, and two Department of Health and Human Services Secretary's Distinguished Service Awards.

Selected Publications

  1. Snitkin ES, Zelazny AM, Thomas PJ, Stock F, NISC Comparative Sequencing Program Group, Henderson DK, Palmore TN, Segre JA. Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med. 2012;4(148):148ra116.

  2. Henderson DK. Management of needlestick injuries: a house officer who has a needlestick. JAMA. 2012;307(1):75-84.

  3. Turkel S, Henderson DK. Current strategies for managing providers infected with bloodborne pathogens. Infect Control Hosp Epidemiol. 2011;32(5):428-34.

  4. Palmore TN, Michelin AV, Bordner M, Odom RT, Stock F, Sinaii N, Fedorko DP, Murray PR, Henderson DK. Use of adherence monitors as part of a team approach to control clonal spread of multidrug-resistant Acinetobacter baumannii in a research hospital. Infect Control Hosp Epidemiol. 2011;32(12):1166-72.

  5. Lee LM, Henderson DK. Tolerability of postexposure antiretroviral prophylaxis for occupational exposures to HIV. Drug Saf. 2001;24(8):587-97.

This page was last updated on May 1st, 2013