Christian S. Hinrichs, M.D.
Lasker Clinical Research Scholar
Experimental Transplantation and Immunotherapy Branch
Building 10, Room 4B04
Bethesda, MD 20892
Cellular Therapy for Cancer
Dr. Hinrichs conducts basic and clinical research to discover and develop novel T cell therapies for the treatment of patients with cancer. This work includes a clinical trial of human papillomavirus (HPV)-targeted tumor-infiltrating T cells for patients with HPV+ cancers, which has demonstrated that this treatment can mediate complete regression of cervical cancer in some patients. Dr. Hinrichs' laboratory also has discovered genes for T cell receptors that target HPV, and his group is testing new gene therapy treatments based on these receptors for patients with advanced HPV+ tumors.
Dr. Hinrichs received his B.A. and M.D. degrees from the combined 6-year program at the University of Missouri - Kansas City (UMKC). He trained in general surgery at UMKC and in surgical oncology at Roswell Park Cancer Institute. He then completed a surgical oncology and tumor immunology fellowship at the National Cancer Institute (NCI). Subsequently he trained in internal medicine at George Washington University and in medical oncology at the Medical Oncology Branch of the NCI. Dr. Hinrichs conducts basic research and clinical research to develop T-cell therapies for HPV-associated cancers and other epithelial malignancies.
Stevanović S, Pasetto A, Helman SR, Gartner JJ, Prickett TD, Howie B, Robins HS, Robbins PF, Klebanoff CA, Rosenberg SA, Hinrichs CS. Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer. Science. 2017;356(6334):200-205.
Stevanović S, Draper LM, Langhan MM, Campbell TE, Kwong ML, Wunderlich JR, Dudley ME, Yang JC, Sherry RM, Kammula US, Restifo NP, Rosenberg SA, Hinrichs CS. Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells. J Clin Oncol. 2015;33(14):1543-50.
Draper LM, Kwong ML, Gros A, Stevanović S, Tran E, Kerkar S, Raffeld M, Rosenberg SA, Hinrichs CS. Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6. Clin Cancer Res. 2015;21(19):4431-9.
Hinrichs CS, Rosenberg SA. Exploiting the curative potential of adoptive T-cell therapy for cancer. Immunol Rev. 2014;257(1):56-71.
Hinrichs CS, Restifo NP. Reassessing target antigens for adoptive T-cell therapy. Nat Biotechnol. 2013;31(11):999-1008.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
This page was last updated on October 25th, 2019