Brid M. Ryan, Ph.D., M.P.H.

Stadtman Investigator

Laboratory of Human Carcinogenesis


Building 37, Room 3060C
Bethesda, MD 20892


Research Topics


A Dialogue on Cancer Disparities, Prevention, and Research

Our research program addresses several unanswered questions in lung cancer using an approach that integrates epidemiological, experimental and translational research. Disparities in lung cancer incidence, especially amongst men, have been evident for several decades. However, the potential etiological, genetic, and biological reasons behind these differences are underexplored and not well understood. Our laboratory investigates the science behind these health disparities and is using a multidisciplinary approach to address this question. Our laboratory is also interested in applying a biological framework to understanding the mechanism of interaction between genetics and environment with regard to lung carcinogenesis. Specifically, we have an interest in both early and adult life exposures and mechanistically understanding how they mediate lung cancer risk later in life.


Dr. Ryan completed her undergraduate training in biochemistry at University College Cork, Ireland, in 2001. She received her Ph.D in Cancer Biology from University College Dublin and in 2005 was accepted into the NCI Cancer Prevention Fellowship Program. In 2007, she completed a Masters of Public Health at University College Dublin. She worked under the mentorship of Dr Curtis Harris during her postdoctoral training at the National Cancer Institute. In 2013, she became an NCI Earl Stadtman tenure track investigator at the NCI.

Selected Publications

  1. Meaney CL, Zingone A, Brown D, Yu Y, Cao L, Ryan BM. Identification of serum inflammatory markers as classifiers of lung cancer mortality for stage I adenocarcinoma. Oncotarget. 2017;8(25):40946-40957.

  2. Pine SR, Mechanic LE, Enewold L, Bowman ED, Ryan BM, Cote ML, Wenzlaff AS, Loffredo CA, Olivo-Marston S, Chaturvedi A, Caporaso NE, Schwartz AG, Harris CC. Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans. Cancer Epidemiol Biomarkers Prev. 2016;25(3):488-97.

  3. Ryan BM. Differential eligibility of African American and European American lung cancer cases using LDCT screening guidelines. BMJ Open Respir Res. 2016;3(1):e000166.

  4. Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC. Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. Cancer Res. 2015;75(3):566-75.

  5. Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc Natl Acad Sci U S A. 2010;107(5):2195-200.

This page was last updated on June 9th, 2020