Benes Louis Trus, Ph.D.

Senior Investigator

Imaging Sciences Laboratory


Building 12A, Room 2033
MSC 5624
12 South Drive
Bethesda, MD 20892-5624


Research Topics

Dr. Trus is interested in Image Processing, Electron Microscopy, 3D Reconstruction, and Virus Structures, in particular the Papillomavirus, the Herpesvirus, and RNA containing viruses. He is also interested in Structural Biology and Computational Bioscience.


Dr. Trus obtained his Ph.D. in 1972 from the California Institute of Technology. He joined NIDR in 1975 as a Staff Fellow, moved to CIT (then DCRT) in 1980 and joined NIAMS, as a joint position with CIT, in 1990. In 1993 he became Chief of the Image Processing Research Section in CIT/CBEL, which became a laboratory in 2002. In 2007, he became Acting Scientific Directory of CIT and Acting Director of CIT's Division of Computational Bioscience.

Amongst his achievements, he has two NIH Director's Awards (1987, 1994) and two NIH Group Merit Awards (presented by NIAMS), one in 1998 and the other in 2006.

Selected Publications

  1. Buck CB, Cheng N, Thompson CD, Lowy DR, Steven AC, Schiller JT, Trus BL. Arrangement of L2 within the papillomavirus capsid. J Virol. 2008;82(11):5190-7.

  2. Trus BL, Newcomb WW, Cheng N, Cardone G, Marekov L, Homa FL, Brown JC, Steven AC. Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids. Mol Cell. 2007;26(4):479-89.

  3. Trus BL, Heymann JB, Nealon K, Cheng N, Newcomb WW, Brown JC, Kedes DH, Steven AC. Capsid structure of Kaposi's sarcoma-associated herpesvirus, a gammaherpesvirus, compared to those of an alphaherpesvirus, herpes simplex virus type 1, and a betaherpesvirus, cytomegalovirus. J Virol. 2001;75(6):2879-90.

  4. Trus BL, Roden RB, Greenstone HL, Vrhel M, Schiller JT, Booy FP. Novel structural features of bovine papillomavirus capsid revealed by a three-dimensional reconstruction to 9 A resolution. Nat Struct Biol. 1997;4(5):413-20.

This page was last updated on March 28th, 2019