Angela Ballesteros Morcillo, Ph.D.
Section on Sensory Physiology and Biophysics
The Section on Sensory Physiology and Biophysics focuses on the relationship between the mechanoelectrical transduction (MET) channel complex and sensory inner ear hair cell physiology.
The lab's broad goal is to decipher the fundamental relationships between the MET apparatus and sensory hair cell homeostasis that underlie sensory hair cell death and survival to prevent hearing loss and balance disorders.
Dr. Ballesteros received her Ph.D. from the Autonomous University of Madrid, Spain, with a focus on structural biology. After a short postdoctoral position at the U.S. Food and Drug Administration, she joined NIDCD as a Robert Wenthold postdoctoral fellow under the co-mentorship of Andrew Griffith, M.D., Ph.D., (Dr. Griffith is now at the University of Tennessee) and Bechara Kachar, M.D., to study the molecular biology of proteins essential for hearing. She continued her postdoctoral work in the laboratory of Kenton Swartz, Ph.D., of the National Institute of Neurological Disorders and Stroke (NINDS), focusing on identifying the mechanoelectrical transducer (MET) channel related to the perception of sound and the ability to balance.
Dr. Ballesteros is an NIH Stadtman Tenure-Track Investigator and a 2022 NIH Distinguished Scholar.
- Ballesteros A, Swartz KJ. Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing. Sci Adv. 2022;8(31):eabm5550.
- Ballesteros A, Fenollar-Ferrer C, Swartz KJ. Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins. Elife. 2018;7.
- Ballesteros A, Yadav M, Cui R, Kurima K, Kachar B. Selective binding and transport of protocadherin 15 isoforms by stereocilia unconventional myosins in a heterologous expression system. Sci Rep. 2022;12(1):13764.
- Ballesteros A, Fitzgerald TS, Swartz KJ. Expression of a membrane-targeted fluorescent reporter disrupts auditory hair cell mechanoelectrical transduction and causes profound deafness. Hear Res. 2021;404:108212.
- Beurg M, Schimmenti LA, Koleilat A, Amr SS, Oza A, Barlow AJ, Ballesteros A, Fettiplace R. New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells. J Neurosci. 2021;41(20):4378-4391.
Related Scientific Focus Areas
Molecular Biology and Biochemistry
This page was last updated on Wednesday, August 9, 2023