Alexxai V. Kravitz, Ph.D.
Eating and Addiction Section, Diabetes, Endocrinology, and Obesity Branch
Building 10, Room 5-5932
10 Center Drive
Bethesda, MD 20814
The goal of our research is to understand how different diets can change the function of basal ganglia circuits and how these changes contribute to obesity.
I am interested in the study of basal ganglia circuits and how their function changes in disease states such as obesity, addiction, and depression. Under normal conditions, the basal ganglia drives animals toward the selection of specific behavioral outcomes. Learning can bias this selection process toward specific behavior by altering synapses within and outside the basal ganglia. In extreme cases, these synaptic alterations can produce pathological behavioral selection, as in obesity or addiction. Using behavioral testing, optogenetics, and in vivo electrophysiology and optical measurements, the lab characterizes changes in behavior following learning in a feeding context and attempts to understand the neural correlates and causes of these changes in behavior.
Applying our Research
The circuits we are studying may represent therapeutic targets that can help people change their feeding behavior and ultimately reduce obesity. Additionally, basic science can help the public learn about the brain changes associated with obesity and understand why it is so difficult for obese individuals to change their behavior.
Need for Further Study
Despite ongoing research, it remains unclear how diets high in fat and calories affect reward circuitry in the brain and how to reverse such changes to combat obesity.
- Postdoc, Gladstone Institutes of Neurological Disease, 2009-2013
- Ph.D., University of Pennsylvania, 2009
- B.A., Wesleyan University, 2001
Friend DM, Devarakonda K, O'Neal TJ, Skirzewski M, Papazoglou I, Kaplan AR, Liow JS, Guo J, Rane SG, Rubinstein M, Alvarez VA, Hall KD, Kravitz AV. Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. Cell Metab. 2017;25(2):312-321.
Kravitz AV, Kreitzer AC. Striatal mechanisms underlying movement, reinforcement, and punishment. Physiology (Bethesda). 2012;27(3):167-77.
Kravitz AV, Tye LD, Kreitzer AC. Distinct roles for direct and indirect pathway striatal neurons in reinforcement. Nat Neurosci. 2012;15(6):816-8.
O'Neal TJ, Friend DM, Guo J, Hall KD, Kravitz AV. Increases in Physical Activity Result in Diminishing Increments in Daily Energy Expenditure in Mice. Curr Biol. 2017;27(3):423-430.
Lemos JC, Friend DM, Kaplan AR, Shin JH, Rubinstein M, Kravitz AV, Alvarez VA. Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling. Neuron. 2016;90(4):824-38.