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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Scientific Director: Michael W. Krause, Ph.D.

The Intramural Research Program (IRP) of the NIDDK conducts basic, translational, and clinical biomedical research related to diabetes mellitus, endocrine, bone and metabolic diseases; digestive diseases, including liver diseases and nutritional disorders; kidney diseases; and hematologic diseases.

The research conducted in the IRP spans the breadth of modern biomedical investigation, from basic science to clinical studies. A sampling of areas under study includes:

  • Biophysics – studies of protein folding, development of optical and vibrational imaging, and theory of protein dynamics
  • Cell biology – studies of nuclear import/export, intracellular protein and lipid trafficking, cellular migration and prions
  • Chemical biology and medicinal chemistry – synthesis and characterization of novel compounds and discovery of biologically active natural products
  • Developmental biology – studies using model systems ranging from slime molds to vertebrates to human cells
  • Genetics, pathogenesis, and novel therapies of disease – studies of diabetes types 1 and 2, hepatitis, lipodystrophy, multiple endocrine neoplasia, nephritis/nephropathy, obesity, sickle cell anemia, and transplantation
  • Molecular biology – studies of chromatin structure and function, transcriptional regulation, and DNA recombination
  • Signal transduction – basic and human disease-oriented studies of GTP-binding proteins and protein-coupled receptors, tyrosine kinase receptors, and nuclear hormone receptors
  • Structural biology – studies using x-ray crystallography and NMR spectroscopy

Learn more about the National Institute of Diabetes and Digestive and Kidney Diseases’ Intramural Research Program.