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National Heart, Lung, and Blood Institute (NHLBI)

Scientific Director: Robert S. Balaban, Ph.D.

The mission of the NHLBI Division of Intramural Research (DIR) is to perform robust scientific and clinical research leading to a better understanding of biology and clinical pathology. To attain this goal, the NHLBI DIR has a strong basic science foundation, coupled closely with innovative technology development and outstanding clinical investigators performing research both at the NIH Clinical Research Center and in partnership with local hospitals. Providing state-of-the-art training in basic, translational, and clinical research for the next generation of scientific and clinical leaders is a high priority.

The purview of research is broad, ranging from investigations of basic principles of molecules, cellular, and organ-level physiology. This insight is then used for a better understanding of disease mechanisms to establish new diagnostic and therapeutic approaches. Some current areas of fundamental biologic interest include single molecule structure; protein assembly; molecular and cell biology; cell signaling and motility; membrane trafficking; physiology; systems biology; engineering and technology development. The DIR is also very involved in conducting concept-based clinical studies in the areas of interventional and surgical cardiology; pulmonary medicine; sickle cell anemia; bone marrow transplant; and hematologic disorders. The Center for Population Studies located in Framingham Massachusetts and associated with the Framingham Heart Study focuses on Epidemiology of cardiovascular disease.

This program provides opportunities for scientists and trainees to work together towards a better understanding of molecular machines, the cell, the body, and ultimately the treatment of human diseases.

Learn more about the National Heart, Lung, and Blood Institute’s Division of Intramural Research.