Tenure-Track Investigator, CARD, NIA
Review begins: October 25, 2021
he National Institute on Aging (NIA) Intramural Research Program (IRP), a major research component of the National Institutes of Health (NIH) in the Department of Health and Human Services (DHHS), is seeking applications from highly motivated individuals for the position of Tenure-Track Investigator 1 (Research) in the Center for Alzheimer’s and Related Dementias (CARD), located in Bethesda, MD. The successful candidate will establish an independent research program in translating complex genetic risk underlying Alzheimer’s disease and/or Alzheimer’s disease related dementias (AD/ADRD) into disease-relevant mechanistic insights.
The successful candidate will develop an independent research program focused on translating the accumulating knowledge of the genetic basis of complex AD/ADRD into biological understanding of disease processes. This involves determining the cellular context(s), risk alleles, effector genes, and mechanisms linked to common and rare risk loci identified by genome wide association and sequencing efforts in AD/ADRD. While this position is focused on understanding the biology of complex risk, rather than simple monogenic disease, it is to be expected that there will be significant interaction with existing groups working in the monogenic space both within and outside of CARD. The successful candidate will have a strong background and extensive experience in neurogenetics, high-content genomics, and data science. There are growing genomic data resources from relevant individuals and tissues for AD/ADRD including those aimed at revealing chromatin accessibility, chromatin organization, epigenetic marks, and transcriptional activity from brain, and single-cell populations. The successful applicant will use these existing data but will also be expected to play a role in overseeing the expansion of such data, through ongoing acquisition, particularly in tissues and derived materials from underrepresented individuals. There will be significant support within CARD to enable such data production and analysis. This work will complement other ongoing and developing programs within CARD. Preference will be given to those with demonstrated experience in neurodegeneration, single-cell genomics, and with a strong track record of collaborative research.
The position includes an attractive start-up package and operating budget, including access to comprehensive NIA core facilities and to the unique and extensive resources of the NIH.
CARD is a collaborative initiative between the NIA and National Institute of Neurological Disorders and Stroke (NINDS) that supports basic, translational, and clinical research on AD/ADRD. CARD’s central mission is to initiate, stimulate, accelerate, and support research that will lead to the development of improved treatments and preventions for these diseases. The new Center serves as a collaborative hub for research in the AD/ADRD space, leveraging the highly collaborative and collegial nature of the Intramural Research Program.
Eligible candidates must have a Ph.D. or M.D. (or M.D., Ph.D.) or equivalent doctoral degree in neuroscience, genetics, genomics, or related fields. The incumbent will play a major role in training staff and postdoctoral fellows and maintaining research continuity within CARD, as well as developing a network of intra- and extramural collaborations. The candidate’s capabilities must be demonstrated through publications in high-quality peer-reviewed journals in the relevant field(s). The incumbent is expected to demonstrate peer recognition of their specific contributions.
Salary is commensurate with experience and accomplishments. A full Civil Service package of benefits (including retirement, health, life, and long-term care insurance, Thrift Savings Plan, etc.) is available. All employees of the Federal Government are subject to the conflict-of-interest statutes and regulations, including the Standards of Ethical Conduct. Additional information regarding CARD is available at the following website: https://www.nia.nih.gov/research/card.
To apply, please send cover letter, curriculum vitae and bibliography (including a description of mentoring and outreach activities, especially those involving women and persons from other groups which are underrepresented in biomedical research), statement of research interest (1-2 pages), and three letters of recommendation (sent directly from the letter writers) to: Angela Prazak, Program Specialist, Office of the Scientific Director, National Institute on Aging; Vacancy #CARD-2021-04-AP; via email: firstname.lastname@example.org. Applications, including letters of recommendation, must reference the Vacancy #CARD-2021-04-AP for consideration. The first round of reviews is expected to occur on or about October 25, 2021; however, applications will be accepted until the position is filled.
DHHS and NIH are Equal Opportunity Employers. The NIH is dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.