Senior Investigator, NIEHS

Review begins: September 16, 2024

The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health (NIH), is recruiting for a Senior Investigator to serve as Chief of the Genome Integrity and Structural Biology Laboratory (GISBL) within the Division of Intramural Research. The NIEHS is located in Research Triangle Park (RTP), near to the University of North Carolina, North Carolina State University, North Carolina Central University and Duke University. 

The NIEHS is a premier research institute where intramural investigators study a wide range of important biologic questions related to effects of the environment on human health. GISBL is composed of seven independent research groups that study fundamental mechanisms of genetic stability and instability, including DNA replication and repair utilizing state-of-the-art structural biology techniques, genetics, biochemistry and cell biology to provide insights into biological processes that modulate the effects of environmental exposures on human health. The GISBL also contains four state-of-the-art core facilities that provide computational chemistry and molecular modeling, cryo-electron microscopy (cryoEM), NMR, and x-ray crystallography support to all of NIEHS and, in the case of cryoEM, for other NIH institutes.


The ideal candidate will be tenure-eligible based on an outstanding record of scholarly achievement, leadership capabilities, and broad interests in understanding biological processes involved in mutagenesis, genome stability, allergenicity, mitochondrial function, inflammation, and epigenetic regulation. In addition to directing an independent research program, the Chief will be responsible for leading GISBL and providing vision and directions as research in genome integrity, structural biology and environmental health science continues to evolve. Principal investigators in the NIH intramural program engage directly in high risk/high reward research with postdoctoral fellows, students, and support staff, and collaborate with colleagues to solve important scientific problems. Applicants should have a Ph.D., M.D., or equivalent doctoral degree in a relevant field, and a demonstrated interest in investigating fundamental mechanisms of genetic stability and instability. 

Appointees may be a US citizen, Legal Permanent Resident or non-US citizen who are eligible for a valid work authorization.

This position is subject to a background investigation.


The successful candidate for this position will be eligible for a tenured appointment, and will receive a salary commensurate with experience and accomplishments. The successful candidate will receive full Federal benefits, including leave, health and life insurance, retirement, and savings plan (401K equivalent). 

How to Apply

Applications will be accepted through September 6, 2024. Interested candidates should submit materials as PDFs via email to Bonnie Earnhardt at All emails should include vacancy number AC1612 in the subject line. A complete application includes:

  • Cover Letter including a statement of qualifications for the position and vision for leading the Genome Integrity and Structural Biology Laboratory 
  • Curriculum Vitae including bibliography
  • Statement of commitment to DEIA principles including a description of mentoring and outreach activities, especially those involving underrepresented groups within biomedical research (not to exceed 1 page).
  • Statement of Past Research and Future Plans (not to exceed 4 pages)
  • Arrange for three letters of reference to be sent to Letters should be on official letterhead and signed. Referees must include the applicant’s name and vacancy number AC1612 in the email subject line.

For further information about the position, please contact Dr. Francesco Demayo at Incomplete applications or paper applications will not be accepted. Review of applications will begin on September 16, 2024, and the search will be closed once the position is filled. 

Commitment to Diversity and Equal Employment Opportunity: The NIH NIEHS encourages the application and nomination of qualified women, minorities, and individuals with disabilities. The United States Government prohibits discrimination in employment on the basis of race, color, religion, sex (including pregnancy and gender identity and sexual orientation), national origin, political affiliation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, or other non-merit factors. NIH NIEHS will provide reasonable accommodations to applicants with disabilities as appropriate. If you require reasonable accommodation during any part of the application and hiring process, please notify us. 

Foreign Education:

Applicants who have completed part or all of their education outside of the U.S. must have their foreign education evaluated by an accredited organization to ensure that the foreign education is equivalent to education received in accredited educational institutions in the United States. We will only accept the completed foreign education evaluation. For more information on foreign education verification, visit the National Association of Credential Evaluation Services (NACES) website. Verification must be received prior to the effective date of the appointment. 

Reasonable Accommodation: 

NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis

The NIH is a premier global biomedical research center comprising 27 institutes and centers with more than 18,000 employees supporting all aspects of the NIH mission. For information about the NIH visit


DHHS, NIH, and NIEHS are equal opportunity employers. NIH is dedicated to building a diverse community through its training and employment programs.

This page was last updated on Monday, July 8, 2024