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John R. Bucher, M.S., Ph.D., D.A.B.T.

Senior Scientist
National Toxicology Program
NIEHS
Keystone Building, Room 2132
111 T.W. Alexander Drive
Research Triangle Park, NC 27709
919-541-4532

Research Topics

The National Toxicology Program (NTP) is an interagency DHHS program headquartered at the NIEHS. The goals of the program are to; 1) provide toxicological evaluations on substances of public health concern, 2) develop and validate improved toxicology research and testing methods (more sensitive, specific, and rapid), 3) develop approaches and generate data to strengthen the science base for risk assessments, and 4) communicate results with health regulatory and research agencies, the medical community, affected industries and the public. My specific research interests include characterization of the toxic and carcinogenic potential of a variety of chemicals, mixtures and physical agents of interest to the NTP, and issues related to the improvement of research and analysis tools and assays for these purposes. I have oversight responsibilities for the design, performance and interpretation of NTP toxicology and carcinogenesis studies, for the evaluation and listing of agents in the NTP Report on Carcinogens, for the alternative animal assay evaluation program of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and for the scientific assessments of health effects related to environmental exposures produced by the Office of Health Assessment and Translation.

Recently efforts with the FDA, EPA, and NCATS NIH Chemical Genomics Center have focused on establishing a new research and testing paradigm for predictive toxicology by exposing libraries of thousands of chemicals in high through put screening assays against a wide variety of cellular and biochemical based targets, and examining the capacity of these environmental chemicals, drugs and complex mixtures to perturb pathways that are activated or repressed in various toxicities and diseases. Additional activities include guidance for the development and application of systematic review procedures to the field of environmental health sciences, which represents a leap in complexity beyond the current primary application to experimental medicine and randomized clinical trials.

Biography

Dr. Bucher is the Associate Director of the NTP and Director of the Division of the NTP at the National Institute of Environmental Health Sciences. He holds a Ph.D. in pharmacology from the University of Iowa, an M.S. in biochemistry from the University of North Carolina, and a B.A. in biology from Knox College. He was an NIH Postdoctoral Fellow in Biochemistry and Environmental Toxicology at Michigan State. Bucher is a Diplomate' of the American Board of Toxicology, a fellow of the Collegium Ramazzini, and recipient of the Doerenkamp-Zbinden Foundation Award for Animal Protection in Science, along with numerous NIH awards.

Selected Publications

  1. Melnick RL, Thayer KA, Bucher JR. Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. Environ Health Perspect. 2008;116(1):130-5.
  2. Collins FS, Gray GM, Bucher JR. Toxicology. Transforming environmental health protection. Science. 2008;319(5865):906-7.
  3. Walker NJ, Bucher JR. A 21st century paradigm for evaluating the health hazards of nanoscale materials? Toxicol Sci. 2009;110(2):251-4.
  4. Thayer KA, Heindel JJ, Bucher JR, Gallo MA. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect. 2012;120(6):779-89.
  5. Tice RR, Austin CP, Kavlock RJ, Bucher JR. Improving the Human Hazard Characterization of Chemicals: A Tox21 Update. Environ Health Perspect. 2013.
This page was last updated on April 26th, 2013