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Dimiter S. Dimitrov, Ph.D.

Senior Investigator
Laboratory of Experimental Immunology
NCI/CCR
Building 469, Room 150B
P.O. Box B
Frederick MD, 21702-1201
301-846-1352

Research Topics

Protein Interactions

Protein interactions are important for understanding of biological function, and for prevention, diagnosis and treatment of diseases. Our research focuses on antibody-antigen and ligand-receptor interactions. We identify novel human monoclonal antibodies, characterize and improve their properties, elucidate their mechanisms of interactions, investigate antibody-mediated modulation of ligand-receptor interactions, and apply the knowledge gained to solve biomedical problems. Our major long-term goal is to develop antibody-based therapeutics including engineered antibody domains and antibody-guided nanoparticles against cancer and other diseases. Currently, we identify, engineer and characterize antibodies against components of the insulin-like growth factor (IGF) system and other cancer-related proteins, HIV, and emerging and biodefense-related microbes including Nipah and Hendra viruses, and dengue virus. We also study mechanisms of antibody elicitation and proposed a new (germline/maturation) concept with implications for development of vaccines against AIDS and other diseases.

Biography

Dr. Dimitrov obtained his Ph.D. in chemistry at the University of Sofia, and his Sc.D. in biology at the Bulgarian Academy of Sciences, where he was elected as a Professor of Biophysics. He was appointed to the Senior Biomedical Research Service at NIH and selected as an NCI outstanding mentor. His research focuses on development of human monoclonal antibodies including isolated engineered antibody domains for prevention and treatment of cancer and other diseases.

Selected Publications

  1. Tang Z, Feng M, Gao W, Phung Y, Chen W, Chaudhary A, St Croix B, Qian M, Dimitrov DS, Ho M. A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface. Mol Cancer Ther. 2013;12(4):416-26.
  2. Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH, Dimitrov DS, Morgan RA, FitzGerald DJ, Barrett DM, Wayne AS, Mackall CL, Orentas RJ. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2013;121(7):1165-74.
  3. Chen W, Ying T, Dimitrov DS. Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design. Expert Opin Biol Ther. 2013;13(5):657-71.
  4. Zhu Z, Prabakaran P, Chen W, Broder CC, Gong R, Dimitrov DS. Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1. Virol Sin. 2013;28(2):71-80.
  5. Meyerson JR, Tran EE, Kuybeda O, Chen W, Dimitrov DS, Gorlani A, Verrips T, Lifson JD, Subramaniam S. Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives. Proc Natl Acad Sci U S A. 2013;110(2):513-8.
This page was last updated on September 30th, 2013